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Oral Glutamine Is Superior Than Oral Glucose to Promote Glycemia Recovery in Mice Submitted to Insulin-Induced Hypoglycemia
Joint Authors
Nunes Santiago, Amanda
Godoi-Gazola, Vilma Aparecida Ferreira de
Fachin Milani, Mariana
Diaz Pedrosa, Maria Montserrat
Bazotte, Roberto Barbosa
de Campos, Vanessa Cristina
Rodrigues Vilela, Vanessa
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The effect of the oral administration of blood glucose precursors on glycemia recovery and liver glucose production in fasted mice subjected to insulin-induced hypoglycemia (IIH) was investigated.
IIH was obtained with increasing doses (from 0.5 to 2.0 U·kg−1) of intraperitoneal regular insulin where glycemia was evaluated from 0 to 300 min after insulin injection.
The dose of 1.0 U·kg−1 showed the best results, that is, a clear glycemia recovery phase without convulsions or deaths.
Thus, this dose was used in all experiments.
Afterwards, mice submitted to IIH received orally by gavage: saline (control group), glucose (100 mg·kg−1), glycerol (100 mg·kg−1), lactate (100 mg·kg−1), alanine (100 mg·kg−1), or glutamine (100 mg·kg−1).
It was observed that glutamine was more effective in promoting glycemia recovery if compared with glucose, lactate, glycerol, or alanine.
In agreement with these results, the best performance in terms of liver glucose production was obtained when glutamine was used as glucose precursors.
These results open perspectives for clinical studies to investigate the impact of oral administration of gluconeogenic amino acids to promote glycemia recovery during hypoglycemia.
American Psychological Association (APA)
Nunes Santiago, Amanda& Godoi-Gazola, Vilma Aparecida Ferreira de& Fachin Milani, Mariana& de Campos, Vanessa Cristina& Rodrigues Vilela, Vanessa& Diaz Pedrosa, Maria Montserrat…[et al.]. 2013. Oral Glutamine Is Superior Than Oral Glucose to Promote Glycemia Recovery in Mice Submitted to Insulin-Induced Hypoglycemia. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-502500
Modern Language Association (MLA)
Nunes Santiago, Amanda…[et al.]. Oral Glutamine Is Superior Than Oral Glucose to Promote Glycemia Recovery in Mice Submitted to Insulin-Induced Hypoglycemia. International Journal of Endocrinology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-502500
American Medical Association (AMA)
Nunes Santiago, Amanda& Godoi-Gazola, Vilma Aparecida Ferreira de& Fachin Milani, Mariana& de Campos, Vanessa Cristina& Rodrigues Vilela, Vanessa& Diaz Pedrosa, Maria Montserrat…[et al.]. Oral Glutamine Is Superior Than Oral Glucose to Promote Glycemia Recovery in Mice Submitted to Insulin-Induced Hypoglycemia. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-502500
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502500