[6]-Shogaol Inhibits α-MSH-Induced Melanogenesis through the Acceleration of ERK and PI3KAkt-Mediated MITF Degradation
المؤلفون المشاركون
Wu, Chia-Yin
Ke, Hui-Ju
Chang, Tsong-Min
Huang, Huey-Chun
Chang, Shu-Jen
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-19
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
[6]-Shogaol is the main biologically active component of ginger.
Previous reports showed that [6]-shogaol has several pharmacological characteristics, such as antioxidative, anti-inflammatory, antimicrobial, and anticarcinogenic properties.
However, the effects of [6]-shogaol on melanogenesis remain to be elucidated.
The study aimed to evaluate the potential skin whitening mechanisms of [6]-shogaol.
The effects of [6]-shogaol on cell viability, melanin content, tyrosinase activity, and the expression of the tyrosinase and microphthalmia-associated transcription factor (MITF) were measured.
The results revealed that [6]-shogaol effectively suppresses tyrosinase activity and the amount of melanin and that those effects are more pronounced than those of arbutin.
It was also found that [6]-shogaol decreased the protein expression levels of tyrosinase-related protein 1 (TRP-1) and microphthalmia-associated transcriptional factor (MITF).
In addition, the MITF mRNA levels were also effectively decreased in the presence of 20 μM [6]-shogaol.
The degradation of MITF protein was inhibited by the MEK 1-inhibitor (U0126) or phosphatidylinositol-3-kinase inhibitor (PI3K inhibitor) (LY294002).
Further immunofluorescence staining assay implied the involvement of the proteasome in the downregulation of MITF by [6]-shogaol.
Our confocal assay results also confirmed that [6]-shogaol inhibited α-melanocyte stimulating hormone- (α-MSH-) induced melanogenesis through the acceleration of extracellular responsive kinase (ERK) and phosphatidylinositol-3-kinase- (PI3K/Akt-) mediated MITF degradation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Huey-Chun& Chang, Shu-Jen& Wu, Chia-Yin& Ke, Hui-Ju& Chang, Tsong-Min. 2014. [6]-Shogaol Inhibits α-MSH-Induced Melanogenesis through the Acceleration of ERK and PI3KAkt-Mediated MITF Degradation. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-502601
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Huey-Chun…[et al.]. [6]-Shogaol Inhibits α-MSH-Induced Melanogenesis through the Acceleration of ERK and PI3KAkt-Mediated MITF Degradation. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-502601
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Huey-Chun& Chang, Shu-Jen& Wu, Chia-Yin& Ke, Hui-Ju& Chang, Tsong-Min. [6]-Shogaol Inhibits α-MSH-Induced Melanogenesis through the Acceleration of ERK and PI3KAkt-Mediated MITF Degradation. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-502601
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-502601
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر