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[6]-Shogaol Inhibits α-MSH-Induced Melanogenesis through the Acceleration of ERK and PI3KAkt-Mediated MITF Degradation
المؤلفون المشاركون
Wu, Chia-Yin
Ke, Hui-Ju
Chang, Tsong-Min
Huang, Huey-Chun
Chang, Shu-Jen
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-19
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
[6]-Shogaol is the main biologically active component of ginger.
Previous reports showed that [6]-shogaol has several pharmacological characteristics, such as antioxidative, anti-inflammatory, antimicrobial, and anticarcinogenic properties.
However, the effects of [6]-shogaol on melanogenesis remain to be elucidated.
The study aimed to evaluate the potential skin whitening mechanisms of [6]-shogaol.
The effects of [6]-shogaol on cell viability, melanin content, tyrosinase activity, and the expression of the tyrosinase and microphthalmia-associated transcription factor (MITF) were measured.
The results revealed that [6]-shogaol effectively suppresses tyrosinase activity and the amount of melanin and that those effects are more pronounced than those of arbutin.
It was also found that [6]-shogaol decreased the protein expression levels of tyrosinase-related protein 1 (TRP-1) and microphthalmia-associated transcriptional factor (MITF).
In addition, the MITF mRNA levels were also effectively decreased in the presence of 20 μM [6]-shogaol.
The degradation of MITF protein was inhibited by the MEK 1-inhibitor (U0126) or phosphatidylinositol-3-kinase inhibitor (PI3K inhibitor) (LY294002).
Further immunofluorescence staining assay implied the involvement of the proteasome in the downregulation of MITF by [6]-shogaol.
Our confocal assay results also confirmed that [6]-shogaol inhibited α-melanocyte stimulating hormone- (α-MSH-) induced melanogenesis through the acceleration of extracellular responsive kinase (ERK) and phosphatidylinositol-3-kinase- (PI3K/Akt-) mediated MITF degradation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Huey-Chun& Chang, Shu-Jen& Wu, Chia-Yin& Ke, Hui-Ju& Chang, Tsong-Min. 2014. [6]-Shogaol Inhibits α-MSH-Induced Melanogenesis through the Acceleration of ERK and PI3KAkt-Mediated MITF Degradation. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-502601
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Huey-Chun…[et al.]. [6]-Shogaol Inhibits α-MSH-Induced Melanogenesis through the Acceleration of ERK and PI3KAkt-Mediated MITF Degradation. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-502601
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Huey-Chun& Chang, Shu-Jen& Wu, Chia-Yin& Ke, Hui-Ju& Chang, Tsong-Min. [6]-Shogaol Inhibits α-MSH-Induced Melanogenesis through the Acceleration of ERK and PI3KAkt-Mediated MITF Degradation. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-502601
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-502601
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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