Heme Oxygenase-1 Induction and Organic Nitrate Therapy : Beneficial Effects on Endothelial Dysfunction, Nitrate Tolerance, and Vascular Oxidative Stress
المؤلفون المشاركون
Oelze, Matthias
Daiber, Andreas
Bollmann, Franziska
Pautz, Andrea
Kleinert, Hartmut
Wenzel, Philip
المصدر
International Journal of Hypertension
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-07
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Organic nitrates are a group of very effective anti-ischemic drugs.
They are used for the treatment of patients with stable angina, acute myocardial infarction, and chronic congestive heart failure.
A major therapeutic limitation inherent to organic nitrates is the development of tolerance, which occurs during chronic treatment with these agents, and this phenomenon is largely based on induction of oxidative stress with subsequent endothelial dysfunction.
We therefore speculated that induction of heme oxygenase-1 (HO-1) could be an efficient strategy to overcome nitrate tolerance and the associated side effects.
Indeed, we found that hemin cotreatment prevented the development of nitrate tolerance and vascular oxidative stress in response to chronic nitroglycerin therapy.
Vice versa, pentaerithrityl tetranitrate (PETN), a nitrate that was previously reported to be devoid of adverse side effects, displayed tolerance and oxidative stress when the HO-1 pathway was blocked pharmacologically or genetically by using HO-1+/– mice.
Recently, we identified activation of Nrf2 and HuR as a principle mechanism of HO-1 induction by PETN.
With the present paper, we present and discuss our recent and previous findings on the role of HO-1 for the prevention of nitroglycerin-induced nitrate tolerance and for the beneficial effects of PETN therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Daiber, Andreas& Oelze, Matthias& Wenzel, Philip& Bollmann, Franziska& Pautz, Andrea& Kleinert, Hartmut. 2012. Heme Oxygenase-1 Induction and Organic Nitrate Therapy : Beneficial Effects on Endothelial Dysfunction, Nitrate Tolerance, and Vascular Oxidative Stress. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-502618
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Daiber, Andreas…[et al.]. Heme Oxygenase-1 Induction and Organic Nitrate Therapy : Beneficial Effects on Endothelial Dysfunction, Nitrate Tolerance, and Vascular Oxidative Stress. International Journal of Hypertension No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-502618
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Daiber, Andreas& Oelze, Matthias& Wenzel, Philip& Bollmann, Franziska& Pautz, Andrea& Kleinert, Hartmut. Heme Oxygenase-1 Induction and Organic Nitrate Therapy : Beneficial Effects on Endothelial Dysfunction, Nitrate Tolerance, and Vascular Oxidative Stress. International Journal of Hypertension. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-502618
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-502618
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر