Heme Oxygenase-1 Induction and Organic Nitrate Therapy : Beneficial Effects on Endothelial Dysfunction, Nitrate Tolerance, and Vascular Oxidative Stress
Joint Authors
Oelze, Matthias
Daiber, Andreas
Bollmann, Franziska
Pautz, Andrea
Kleinert, Hartmut
Wenzel, Philip
Source
International Journal of Hypertension
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-07
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Organic nitrates are a group of very effective anti-ischemic drugs.
They are used for the treatment of patients with stable angina, acute myocardial infarction, and chronic congestive heart failure.
A major therapeutic limitation inherent to organic nitrates is the development of tolerance, which occurs during chronic treatment with these agents, and this phenomenon is largely based on induction of oxidative stress with subsequent endothelial dysfunction.
We therefore speculated that induction of heme oxygenase-1 (HO-1) could be an efficient strategy to overcome nitrate tolerance and the associated side effects.
Indeed, we found that hemin cotreatment prevented the development of nitrate tolerance and vascular oxidative stress in response to chronic nitroglycerin therapy.
Vice versa, pentaerithrityl tetranitrate (PETN), a nitrate that was previously reported to be devoid of adverse side effects, displayed tolerance and oxidative stress when the HO-1 pathway was blocked pharmacologically or genetically by using HO-1+/– mice.
Recently, we identified activation of Nrf2 and HuR as a principle mechanism of HO-1 induction by PETN.
With the present paper, we present and discuss our recent and previous findings on the role of HO-1 for the prevention of nitroglycerin-induced nitrate tolerance and for the beneficial effects of PETN therapy.
American Psychological Association (APA)
Daiber, Andreas& Oelze, Matthias& Wenzel, Philip& Bollmann, Franziska& Pautz, Andrea& Kleinert, Hartmut. 2012. Heme Oxygenase-1 Induction and Organic Nitrate Therapy : Beneficial Effects on Endothelial Dysfunction, Nitrate Tolerance, and Vascular Oxidative Stress. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-502618
Modern Language Association (MLA)
Daiber, Andreas…[et al.]. Heme Oxygenase-1 Induction and Organic Nitrate Therapy : Beneficial Effects on Endothelial Dysfunction, Nitrate Tolerance, and Vascular Oxidative Stress. International Journal of Hypertension No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-502618
American Medical Association (AMA)
Daiber, Andreas& Oelze, Matthias& Wenzel, Philip& Bollmann, Franziska& Pautz, Andrea& Kleinert, Hartmut. Heme Oxygenase-1 Induction and Organic Nitrate Therapy : Beneficial Effects on Endothelial Dysfunction, Nitrate Tolerance, and Vascular Oxidative Stress. International Journal of Hypertension. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-502618
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502618