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Where Do Phosphosites Come from and Where Do They Go after Gene Duplication?
المؤلفون المشاركون
Diss, Guillaume
Freschi, Luca
Landry, Christian R.
المصدر
International Journal of Evolutionary Biology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-20
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Gene duplication followed by divergence is an important mechanism that leads to molecular innovation.
Divergence of paralogous genes can be achieved at functional and regulatory levels.
Whereas regulatory divergence at the transcriptional level is well documented, little is known about divergence of posttranslational modifications (PTMs).
Protein phosphorylation, one of the most important PTMs, has recently been shown to be an important determinant of the retention of paralogous genes.
Here we test whether gains and losses of phosphorylated amino acids after gene duplication may specifically modify the regulation of these duplicated proteins.
We show that when phosphosites are lost in one paralog, transitions from phosphorylated serines and threonines are significantly biased toward negatively charged amino acids, which can mimic their phosphorylated status in a constitutive manner.
Our analyses support the hypothesis that divergence between paralogs can be generated by a loss of the posttranslational regulatory control on a function rather than by the complete loss of the function itself.
Surprisingly, these favoured transitions cannot be reached by single mutational steps, which suggests that the function of a phosphosite needs to be completely abolished before it is restored through substitution by these phosphomimetic residues.
We conclude by discussing how gene duplication could facilitate the transitions between phosphorylated and phosphomimetic amino acids.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Diss, Guillaume& Freschi, Luca& Landry, Christian R.. 2012. Where Do Phosphosites Come from and Where Do They Go after Gene Duplication?. International Journal of Evolutionary Biology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-502683
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Diss, Guillaume…[et al.]. Where Do Phosphosites Come from and Where Do They Go after Gene Duplication?. International Journal of Evolutionary Biology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-502683
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Diss, Guillaume& Freschi, Luca& Landry, Christian R.. Where Do Phosphosites Come from and Where Do They Go after Gene Duplication?. International Journal of Evolutionary Biology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-502683
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-502683
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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