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Where Do Phosphosites Come from and Where Do They Go after Gene Duplication?
Joint Authors
Diss, Guillaume
Freschi, Luca
Landry, Christian R.
Source
International Journal of Evolutionary Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Gene duplication followed by divergence is an important mechanism that leads to molecular innovation.
Divergence of paralogous genes can be achieved at functional and regulatory levels.
Whereas regulatory divergence at the transcriptional level is well documented, little is known about divergence of posttranslational modifications (PTMs).
Protein phosphorylation, one of the most important PTMs, has recently been shown to be an important determinant of the retention of paralogous genes.
Here we test whether gains and losses of phosphorylated amino acids after gene duplication may specifically modify the regulation of these duplicated proteins.
We show that when phosphosites are lost in one paralog, transitions from phosphorylated serines and threonines are significantly biased toward negatively charged amino acids, which can mimic their phosphorylated status in a constitutive manner.
Our analyses support the hypothesis that divergence between paralogs can be generated by a loss of the posttranslational regulatory control on a function rather than by the complete loss of the function itself.
Surprisingly, these favoured transitions cannot be reached by single mutational steps, which suggests that the function of a phosphosite needs to be completely abolished before it is restored through substitution by these phosphomimetic residues.
We conclude by discussing how gene duplication could facilitate the transitions between phosphorylated and phosphomimetic amino acids.
American Psychological Association (APA)
Diss, Guillaume& Freschi, Luca& Landry, Christian R.. 2012. Where Do Phosphosites Come from and Where Do They Go after Gene Duplication?. International Journal of Evolutionary Biology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-502683
Modern Language Association (MLA)
Diss, Guillaume…[et al.]. Where Do Phosphosites Come from and Where Do They Go after Gene Duplication?. International Journal of Evolutionary Biology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-502683
American Medical Association (AMA)
Diss, Guillaume& Freschi, Luca& Landry, Christian R.. Where Do Phosphosites Come from and Where Do They Go after Gene Duplication?. International Journal of Evolutionary Biology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-502683
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502683