The Influence of an Obesogenic Diet on Oxysterol Metabolism in C57BL6J Mice
المؤلفون المشاركون
Perrard, Xiaoyuan Dai
Raya, Joe
Gaubatz, John
Hoogeveen, Ron C.
Wu, Huaizhu
Wooten, Joshua S.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-05
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Our current understanding of oxysterol metabolism during different disease states such as obesity and dyslipidemia is limited.
Therefore, the aim of this study was to determine the effect of diet-induced obesity on the tissue distribution of various oxysterols and the mRNA expression of key enzymes involved in oxysterol metabolism.
To induce obesity, male C57BL/6J mice were fed a high fat-cholesterol diet for 24 weeks.
Following diet-induced obesity, plasma levels of 4β-hydroxycholesterol, 5,6α-epoxycholesterol, 5,6β-epoxycholesterol, 7α-hydroxycholesterol, 7β-hydroxycholesterol, and 27-hydroxycholesterol were significantly (P<0.05) increased.
In the liver and adipose tissue of the obese mice, 4β-hydroxycholesterol was significantly (P<0.05) increased, whereas 27-hydroxycholesterol was increased only in the adipose tissue.
No significant changes in either hepatic or adipose tissue mRNA expression were observed for oxysterol synthesizing enzymes 4β-hydroxylase, 27-hydroxylase, or 7α-hydroxylase.
Hepatic mRNA expression of SULT2B1b, a key enzyme involved in oxysterol detoxification, was significantly (P<0.05) elevated in the obese mice.
Interestingly, the appearance of the large HDL1 lipoprotein was observed with increased oxysterol synthesis during obesity.
In diet-induced obese mice, dietary intake and endogenous enzymatic synthesis of oxysterols could not account for the increased oxysterol levels, suggesting that nonenzymatic cholesterol oxidation pathways may be responsible for the changes in oxysterol metabolism.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wooten, Joshua S.& Wu, Huaizhu& Raya, Joe& Perrard, Xiaoyuan Dai& Gaubatz, John& Hoogeveen, Ron C.. 2014. The Influence of an Obesogenic Diet on Oxysterol Metabolism in C57BL6J Mice. Cholesterol،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-502712
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wooten, Joshua S.…[et al.]. The Influence of an Obesogenic Diet on Oxysterol Metabolism in C57BL6J Mice. Cholesterol No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-502712
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wooten, Joshua S.& Wu, Huaizhu& Raya, Joe& Perrard, Xiaoyuan Dai& Gaubatz, John& Hoogeveen, Ron C.. The Influence of an Obesogenic Diet on Oxysterol Metabolism in C57BL6J Mice. Cholesterol. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-502712
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-502712
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر