In Vitro and In Vivo Leishmanicidal Activity of Astronium fraxinifolium (Schott)‎ and Plectranthus amboinicus (Lour.)‎ Spreng against Leishmania (Viannia)‎ braziliensis

المؤلفون المشاركون

Torres, Alba Fabiola
Teixeira, Maria Jania
de Morais, Selene Maia
Rodrigues, Raphael Oliveira
Santiago, Gilvandete Maria Pinheiro
Martins, Alice Maria Costa
Braga, Milena Aguiar
de Lima, Silvio César Gomes
Nagao-Dias, Aparecida Tiemi
Lopes Júnior, José Evaldo Gonçalves

المصدر

BioMed Research International

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-04-16

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الطب البشري

الملخص EN

The aim of the present work was to evaluate antileishmanial activity of Astronium fraxinifolium and Plectranthus amboinicus.

For the in vitro tests, essential oil of P.

amboinicus (OEPA) and ethanolic extracts from A.

fraxinifolium (EEAF) were incubated with 106 promastigotes of L.

(Viannia) braziliensis.

The OEPA was able to reduce the parasite growth after 48 h; nonetheless, all the EEAFs could totally abolish the parasite growth.

For the in vivo studies, BALB/c mice were infected subcutaneously (s.c.) with 107 L.

braziliensis promastigotes.

Treatment was done by administering OEPA intralesionally (i.l.) for 14 days.

No difference was found in lesion thickness when those animals were compared with the untreated animals.

Further, golden hamsters were infected s.c.

with 106 L.

braziliensis promastigotes.

The first protocol of treatment consisted of ethanolic leaf extract from A.

fraxinifolium (ELEAF) administered i.l.

for 4 days and a booster dose at the 7th day.

The animals showed a significant reduction of lesion thickness in the 6th week, but it was not comparable to the animals treated with Glucantime.

The second protocol consisted of 15 daily intralesional injections.

The profiles of lesion thickness were similar to the standard treatment.

In conclusion, in vivo studies showed a high efficacy when the infected animals were intralesionally treated with leaf ethanolic extract from A.

fraxinifolium.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

de Lima, Silvio César Gomes& Teixeira, Maria Jania& Lopes Júnior, José Evaldo Gonçalves& de Morais, Selene Maia& Torres, Alba Fabiola& Braga, Milena Aguiar…[et al.]. 2014. In Vitro and In Vivo Leishmanicidal Activity of Astronium fraxinifolium (Schott) and Plectranthus amboinicus (Lour.) Spreng against Leishmania (Viannia) braziliensis. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-503033

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

de Lima, Silvio César Gomes…[et al.]. In Vitro and In Vivo Leishmanicidal Activity of Astronium fraxinifolium (Schott) and Plectranthus amboinicus (Lour.) Spreng against Leishmania (Viannia) braziliensis. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-503033

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

de Lima, Silvio César Gomes& Teixeira, Maria Jania& Lopes Júnior, José Evaldo Gonçalves& de Morais, Selene Maia& Torres, Alba Fabiola& Braga, Milena Aguiar…[et al.]. In Vitro and In Vivo Leishmanicidal Activity of Astronium fraxinifolium (Schott) and Plectranthus amboinicus (Lour.) Spreng against Leishmania (Viannia) braziliensis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-503033

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-503033