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In Vitro and In Vivo Leishmanicidal Activity of Astronium fraxinifolium (Schott) and Plectranthus amboinicus (Lour.) Spreng against Leishmania (Viannia) braziliensis
Joint Authors
Torres, Alba Fabiola
Teixeira, Maria Jania
de Morais, Selene Maia
Rodrigues, Raphael Oliveira
Santiago, Gilvandete Maria Pinheiro
Martins, Alice Maria Costa
Braga, Milena Aguiar
de Lima, Silvio César Gomes
Nagao-Dias, Aparecida Tiemi
Lopes Júnior, José Evaldo Gonçalves
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The aim of the present work was to evaluate antileishmanial activity of Astronium fraxinifolium and Plectranthus amboinicus.
For the in vitro tests, essential oil of P.
amboinicus (OEPA) and ethanolic extracts from A.
fraxinifolium (EEAF) were incubated with 106 promastigotes of L.
(Viannia) braziliensis.
The OEPA was able to reduce the parasite growth after 48 h; nonetheless, all the EEAFs could totally abolish the parasite growth.
For the in vivo studies, BALB/c mice were infected subcutaneously (s.c.) with 107 L.
braziliensis promastigotes.
Treatment was done by administering OEPA intralesionally (i.l.) for 14 days.
No difference was found in lesion thickness when those animals were compared with the untreated animals.
Further, golden hamsters were infected s.c.
with 106 L.
braziliensis promastigotes.
The first protocol of treatment consisted of ethanolic leaf extract from A.
fraxinifolium (ELEAF) administered i.l.
for 4 days and a booster dose at the 7th day.
The animals showed a significant reduction of lesion thickness in the 6th week, but it was not comparable to the animals treated with Glucantime.
The second protocol consisted of 15 daily intralesional injections.
The profiles of lesion thickness were similar to the standard treatment.
In conclusion, in vivo studies showed a high efficacy when the infected animals were intralesionally treated with leaf ethanolic extract from A.
fraxinifolium.
American Psychological Association (APA)
de Lima, Silvio César Gomes& Teixeira, Maria Jania& Lopes Júnior, José Evaldo Gonçalves& de Morais, Selene Maia& Torres, Alba Fabiola& Braga, Milena Aguiar…[et al.]. 2014. In Vitro and In Vivo Leishmanicidal Activity of Astronium fraxinifolium (Schott) and Plectranthus amboinicus (Lour.) Spreng against Leishmania (Viannia) braziliensis. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-503033
Modern Language Association (MLA)
de Lima, Silvio César Gomes…[et al.]. In Vitro and In Vivo Leishmanicidal Activity of Astronium fraxinifolium (Schott) and Plectranthus amboinicus (Lour.) Spreng against Leishmania (Viannia) braziliensis. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-503033
American Medical Association (AMA)
de Lima, Silvio César Gomes& Teixeira, Maria Jania& Lopes Júnior, José Evaldo Gonçalves& de Morais, Selene Maia& Torres, Alba Fabiola& Braga, Milena Aguiar…[et al.]. In Vitro and In Vivo Leishmanicidal Activity of Astronium fraxinifolium (Schott) and Plectranthus amboinicus (Lour.) Spreng against Leishmania (Viannia) braziliensis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-503033
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503033