The Mechanisms of Chansu in Inducing Efficient Apoptosis in Colon Cancer Cells
المؤلفون المشاركون
Hashimi, Saeed M.
Mellick, Albert S.
Good, David
Wei, Ming Q.
Li, Chun
Cao, Siyu
Duan, Wei
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-30
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Chansu is one of the most widely used traditional Chinese medicines in China, Japan, and other Southeast Asian countries primarily for antipain, anti-inflammation, and recently anticancer.
Over 10 recipes and remedies contained Chansu, which are easily available in pharmacies and hospitals, but the mechanisms of action were not clearly articulated.
In the present study, Cinobufagin (CBF), the major compound of Chansu, was employed as a surrogate marker to determine its ability in inducing cancer cell death.
As expected, CBF has significant cancer-killing capacity for a range of cancers, but such ability differs markedly.
Colon and prostate cancers are more sensitive than skin and lung cancers.
Interestingly, cancer cells die through apoptotic pathway either being biphasic caspase-3-dependent (HCT116) or independent (HT29).
Multipathway analysis reveals that CBF-induced apoptosis is likely modulated by the hypoxia-inducing factor-1 alpha subunit (HIF-1α) as its inhibition was evident in vitro and in vivo.
Taken together, these results demonstrate that CBF is a potent apoptotic inducer with potential for further development as a novel and effective anticancer agent for a range of cancers, especially colon cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Chun& Hashimi, Saeed M.& Cao, Siyu& Mellick, Albert S.& Duan, Wei& Good, David…[et al.]. 2013. The Mechanisms of Chansu in Inducing Efficient Apoptosis in Colon Cancer Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-503085
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Chun…[et al.]. The Mechanisms of Chansu in Inducing Efficient Apoptosis in Colon Cancer Cells. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-503085
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Chun& Hashimi, Saeed M.& Cao, Siyu& Mellick, Albert S.& Duan, Wei& Good, David…[et al.]. The Mechanisms of Chansu in Inducing Efficient Apoptosis in Colon Cancer Cells. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-503085
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-503085
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر