The Mechanisms of Chansu in Inducing Efficient Apoptosis in Colon Cancer Cells
Joint Authors
Hashimi, Saeed M.
Mellick, Albert S.
Good, David
Wei, Ming Q.
Li, Chun
Cao, Siyu
Duan, Wei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Chansu is one of the most widely used traditional Chinese medicines in China, Japan, and other Southeast Asian countries primarily for antipain, anti-inflammation, and recently anticancer.
Over 10 recipes and remedies contained Chansu, which are easily available in pharmacies and hospitals, but the mechanisms of action were not clearly articulated.
In the present study, Cinobufagin (CBF), the major compound of Chansu, was employed as a surrogate marker to determine its ability in inducing cancer cell death.
As expected, CBF has significant cancer-killing capacity for a range of cancers, but such ability differs markedly.
Colon and prostate cancers are more sensitive than skin and lung cancers.
Interestingly, cancer cells die through apoptotic pathway either being biphasic caspase-3-dependent (HCT116) or independent (HT29).
Multipathway analysis reveals that CBF-induced apoptosis is likely modulated by the hypoxia-inducing factor-1 alpha subunit (HIF-1α) as its inhibition was evident in vitro and in vivo.
Taken together, these results demonstrate that CBF is a potent apoptotic inducer with potential for further development as a novel and effective anticancer agent for a range of cancers, especially colon cancer.
American Psychological Association (APA)
Li, Chun& Hashimi, Saeed M.& Cao, Siyu& Mellick, Albert S.& Duan, Wei& Good, David…[et al.]. 2013. The Mechanisms of Chansu in Inducing Efficient Apoptosis in Colon Cancer Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-503085
Modern Language Association (MLA)
Li, Chun…[et al.]. The Mechanisms of Chansu in Inducing Efficient Apoptosis in Colon Cancer Cells. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-503085
American Medical Association (AMA)
Li, Chun& Hashimi, Saeed M.& Cao, Siyu& Mellick, Albert S.& Duan, Wei& Good, David…[et al.]. The Mechanisms of Chansu in Inducing Efficient Apoptosis in Colon Cancer Cells. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-503085
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503085