Mitochondrial DNA and Functional Investigations into the Radiosensitivity of Four Mouse Strains
المؤلفون المشاركون
Tian, Yeping
Yang, Shanmin
Ma, Jun
Vidyasagar, Sadasivan
Zhang, Steven B.
Zhang, Lurong
Chen, Chun
Zhang, Amy
Guo, Yongson
Litvinchuk, Alexandra
Swarts, Steven
Yin, Liangjie
Zhang, Zhenhuan
Zhang, Mei
Okunieff, Paul
Maguire, David
Casey-Sawicki, Katherine
Han, Deping
Wang, Xiaohui
المصدر
International Journal of Cell Biology
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-12
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
We investigated whether genetic radiosensitivity-related changes in mtDNA/nDNA ratios are significant to mitochondrial function and if a material effect on mtDNA content and function exists.
BALB/c (radiosensitive), C57BL/6 (radioresistant), and F1 hybrid mouse strains were exposed to total body irradiation.
Hepatic genomic DNA was extracted, and mitochondria were isolated.
Mitochondrial oxygen consumption, ROS, and calcium-induced mitochondrial swelling were measured.
Radiation influenced strain-specific survival in vivo.
F1 hybrid survival was influenced by maternal input.
Changes in mitochondrial content corresponded to survival in vivo among the 4 strains.
Calcium-induced mitochondrial swelling was strain dependent.
Isolated mitochondria from BALB/c mice were significantly more sensitive to calcium overload than mitochondria from C57BL/6 mice.
Maternal input partially influenced the recovery effect of radiation on calcium-induced mitochondrial swelling in F1 hybrids; the hybrid with a radiosensitive maternal lineage exhibited a lower rate of recovery.
Hybrids had a survival rate that was biased toward maternal input.
mtDNA content and mitochondrial permeability transition pores (MPTP) measured in these strains before irradiation reflected a dominant input from the parent.
After irradiation, the MPTP opened sooner in radiosensitive and hybrid strains, likely triggering intrinsic apoptotic pathways.
These findings have important implications for translation into predictors of radiation sensitivity/resistance.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Steven B.& Maguire, David& Zhang, Mei& Tian, Yeping& Yang, Shanmin& Zhang, Amy…[et al.]. 2014. Mitochondrial DNA and Functional Investigations into the Radiosensitivity of Four Mouse Strains. International Journal of Cell Biology،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-503212
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Steven B.…[et al.]. Mitochondrial DNA and Functional Investigations into the Radiosensitivity of Four Mouse Strains. International Journal of Cell Biology No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-503212
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Steven B.& Maguire, David& Zhang, Mei& Tian, Yeping& Yang, Shanmin& Zhang, Amy…[et al.]. Mitochondrial DNA and Functional Investigations into the Radiosensitivity of Four Mouse Strains. International Journal of Cell Biology. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-503212
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-503212
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر