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Ultrastructure of Intervertebral Disc and Vertebra-Disc Junctions Zones as a Link in Etiopathogenesis of Idiopathic Scoliosis
المؤلفون المشاركون
Lindley, Emily M.
Noshchenko, Andriy
Patel, Vikas V.
Burger, Evalina L.
Bradford, Andrew P.
المصدر
Advances in Orthopedic Surgery
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-23، 23ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-23
دولة النشر
مصر
عدد الصفحات
23
التخصصات الرئيسية
الملخص EN
Background Context.
There is no general accepted theory on the etiology of idiopathic scoliosis (IS).
An important role of the vertebrae endplate physes (VEPh) and intervertebral discs (IVD) in spinal curve progression is acknowledged, but ultrastructural mechanisms are not well understood.
Purpose.
To analyze the current literature on ultrastructural characteristics of VEPh and IVD in the context of IS etiology.
Study Design/Setting.
A literature review.
Results.
There is strong evidence for multifactorial etiology of IS.
Early wedging of vertebra bodies is likely due to laterally directed appositional bone growth at the concave side, caused by a combination of increased cell proliferation at the vertebrae endplate and altered mechanical properties of the outer annulus fibrosus of the adjacent IVD.
Genetic defects in bending proteins necessary for IVD lamellar organization underlie altered mechanical properties.
Asymmetrical ligaments, muscular stretch, and spine instability may also play roles in curve formation.
Conclusions.
Development of a reliable, cost effective method for identifying patients at high risk for curve progression is needed and could lead to a paradigm shift in treatment options.
Unnecessary anxiety, bracing, and radiation could potentially be minimized and high risk patient could receive surgery earlier, rendering better outcomes with fewer fused segments needed to mitigate curve progression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Burger, Evalina L.& Noshchenko, Andriy& Patel, Vikas V.& Lindley, Emily M.& Bradford, Andrew P.. 2014. Ultrastructure of Intervertebral Disc and Vertebra-Disc Junctions Zones as a Link in Etiopathogenesis of Idiopathic Scoliosis. Advances in Orthopedic Surgery،Vol. 2014, no. 2014, pp.1-23.
https://search.emarefa.net/detail/BIM-503231
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Burger, Evalina L.…[et al.]. Ultrastructure of Intervertebral Disc and Vertebra-Disc Junctions Zones as a Link in Etiopathogenesis of Idiopathic Scoliosis. Advances in Orthopedic Surgery No. 2014 (2014), pp.1-23.
https://search.emarefa.net/detail/BIM-503231
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Burger, Evalina L.& Noshchenko, Andriy& Patel, Vikas V.& Lindley, Emily M.& Bradford, Andrew P.. Ultrastructure of Intervertebral Disc and Vertebra-Disc Junctions Zones as a Link in Etiopathogenesis of Idiopathic Scoliosis. Advances in Orthopedic Surgery. 2014. Vol. 2014, no. 2014, pp.1-23.
https://search.emarefa.net/detail/BIM-503231
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-503231
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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