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Ultrastructure of Intervertebral Disc and Vertebra-Disc Junctions Zones as a Link in Etiopathogenesis of Idiopathic Scoliosis
Joint Authors
Lindley, Emily M.
Noshchenko, Andriy
Patel, Vikas V.
Burger, Evalina L.
Bradford, Andrew P.
Source
Advances in Orthopedic Surgery
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-23
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
Background Context.
There is no general accepted theory on the etiology of idiopathic scoliosis (IS).
An important role of the vertebrae endplate physes (VEPh) and intervertebral discs (IVD) in spinal curve progression is acknowledged, but ultrastructural mechanisms are not well understood.
Purpose.
To analyze the current literature on ultrastructural characteristics of VEPh and IVD in the context of IS etiology.
Study Design/Setting.
A literature review.
Results.
There is strong evidence for multifactorial etiology of IS.
Early wedging of vertebra bodies is likely due to laterally directed appositional bone growth at the concave side, caused by a combination of increased cell proliferation at the vertebrae endplate and altered mechanical properties of the outer annulus fibrosus of the adjacent IVD.
Genetic defects in bending proteins necessary for IVD lamellar organization underlie altered mechanical properties.
Asymmetrical ligaments, muscular stretch, and spine instability may also play roles in curve formation.
Conclusions.
Development of a reliable, cost effective method for identifying patients at high risk for curve progression is needed and could lead to a paradigm shift in treatment options.
Unnecessary anxiety, bracing, and radiation could potentially be minimized and high risk patient could receive surgery earlier, rendering better outcomes with fewer fused segments needed to mitigate curve progression.
American Psychological Association (APA)
Burger, Evalina L.& Noshchenko, Andriy& Patel, Vikas V.& Lindley, Emily M.& Bradford, Andrew P.. 2014. Ultrastructure of Intervertebral Disc and Vertebra-Disc Junctions Zones as a Link in Etiopathogenesis of Idiopathic Scoliosis. Advances in Orthopedic Surgery،Vol. 2014, no. 2014, pp.1-23.
https://search.emarefa.net/detail/BIM-503231
Modern Language Association (MLA)
Burger, Evalina L.…[et al.]. Ultrastructure of Intervertebral Disc and Vertebra-Disc Junctions Zones as a Link in Etiopathogenesis of Idiopathic Scoliosis. Advances in Orthopedic Surgery No. 2014 (2014), pp.1-23.
https://search.emarefa.net/detail/BIM-503231
American Medical Association (AMA)
Burger, Evalina L.& Noshchenko, Andriy& Patel, Vikas V.& Lindley, Emily M.& Bradford, Andrew P.. Ultrastructure of Intervertebral Disc and Vertebra-Disc Junctions Zones as a Link in Etiopathogenesis of Idiopathic Scoliosis. Advances in Orthopedic Surgery. 2014. Vol. 2014, no. 2014, pp.1-23.
https://search.emarefa.net/detail/BIM-503231
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503231