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Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells
المؤلفون المشاركون
Zhong, Zhang-Feng
Wang, Yi-Tao
Lee, Simon Ming-Yuen
Zhang, Qing-Wen
Bao, Jiao-Lin
Hoi, Pui-Man
Chen, Mei-Wan
Li, Ying-Bo
Wu, Guo-Sheng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-02
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Curcuminoids are well known for their capabilities to combat risk factors that are associated with ageing and cellular senescence.
Recent reports have demonstrated that curcuminoids can extend the lifespan of model organisms.
However, the underlying mechanisms by which these polyphenic compounds exert these beneficial effects remain unknown.
In this study, t-BHP-induced premature senescence model in human fibroblasts was chosen to explore the protective effects of a curcuminoid, bisdemethoxycurcumin (BDMC), on cellular senescence.
The results demonstrated that BDMC attenuated oxidative stress-induced senescence-like features which include the induction of an enlarged cellular appearance, higher frequency of senescence-associated β-galactosidase staining activity, appearance of senescence-associated heterochromatic foci in nuclei, decrease in proliferation capability, and alteration in related molecules such as p16 and retinoblastoma protein.
Notably, we found that BDMC treatment activated Sirt1/AMPK signaling pathway.
Moreover, downregulating Sirt1 by the pharmacological inhibitor nicotianamine or small interfering RNA blocked BDMC-mediated protection against t-BHP-mediated decrease in proliferation.
These results suggested that BDMC prevented t-BHP-induced cellular senescence, and BDMC-induced Sirt1 may be a mechanism mediating its beneficial effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Ying-Bo& Zhong, Zhang-Feng& Chen, Mei-Wan& Bao, Jiao-Lin& Wu, Guo-Sheng& Zhang, Qing-Wen…[et al.]. 2013. Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-503339
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Ying-Bo…[et al.]. Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-503339
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Ying-Bo& Zhong, Zhang-Feng& Chen, Mei-Wan& Bao, Jiao-Lin& Wu, Guo-Sheng& Zhang, Qing-Wen…[et al.]. Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-503339
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-503339
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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