Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells
Joint Authors
Zhong, Zhang-Feng
Wang, Yi-Tao
Lee, Simon Ming-Yuen
Zhang, Qing-Wen
Bao, Jiao-Lin
Hoi, Pui-Man
Chen, Mei-Wan
Li, Ying-Bo
Wu, Guo-Sheng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Curcuminoids are well known for their capabilities to combat risk factors that are associated with ageing and cellular senescence.
Recent reports have demonstrated that curcuminoids can extend the lifespan of model organisms.
However, the underlying mechanisms by which these polyphenic compounds exert these beneficial effects remain unknown.
In this study, t-BHP-induced premature senescence model in human fibroblasts was chosen to explore the protective effects of a curcuminoid, bisdemethoxycurcumin (BDMC), on cellular senescence.
The results demonstrated that BDMC attenuated oxidative stress-induced senescence-like features which include the induction of an enlarged cellular appearance, higher frequency of senescence-associated β-galactosidase staining activity, appearance of senescence-associated heterochromatic foci in nuclei, decrease in proliferation capability, and alteration in related molecules such as p16 and retinoblastoma protein.
Notably, we found that BDMC treatment activated Sirt1/AMPK signaling pathway.
Moreover, downregulating Sirt1 by the pharmacological inhibitor nicotianamine or small interfering RNA blocked BDMC-mediated protection against t-BHP-mediated decrease in proliferation.
These results suggested that BDMC prevented t-BHP-induced cellular senescence, and BDMC-induced Sirt1 may be a mechanism mediating its beneficial effects.
American Psychological Association (APA)
Li, Ying-Bo& Zhong, Zhang-Feng& Chen, Mei-Wan& Bao, Jiao-Lin& Wu, Guo-Sheng& Zhang, Qing-Wen…[et al.]. 2013. Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-503339
Modern Language Association (MLA)
Li, Ying-Bo…[et al.]. Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-503339
American Medical Association (AMA)
Li, Ying-Bo& Zhong, Zhang-Feng& Chen, Mei-Wan& Bao, Jiao-Lin& Wu, Guo-Sheng& Zhang, Qing-Wen…[et al.]. Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-503339
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503339