Use of Propolis Hydroalcoholic Extract to Treat Colitis Experimentally Induced in Rats by 2,4,6-Trinitrobenzenesulfonic Acid
المؤلفون المشاركون
Franco, Selma Lucy
Hernandes, Luzmarina
Gonçalves, Cely Cristina Martins
Natali, Maria Raquel Marçal
Silva, Joaquim Felipe de Souza
Bersani-Amado, Ciomar Aparecida
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-11
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
This study focused on the therapeutic effect of a propolis SLNC 106PI extract on experimental colitis.
Wistar adult rats received 0.8 mL rectal dose of one of the following solutions: saline (group S), 20 mg TNBS in 50% ethanol (group TNBS), 20 mg TNBS in 50% ethanol and propolis extract in saline (group TNBS-P), propolis extract in saline (group SP), and 20 mg TNBS in 50% ethanol and 50 mg/kg mesalazine (group TNBS-M).
The animals were euthanized 7 or 14 days after the colitis induction.
Samples of the distal colon were harvested for the analysis of myeloperoxidase (MPO) enzyme activity and for morphometric analysis in paraffin-embedded histological sections with hematoxylin-eosin or histochemical staining.
The animals treated with TNBS exhibited the typical clinical signs of colitis.
Increased MPO activity confirmed the presence of inflammation.
TNBS induced the development of megacolon, ulceration, transmural inflammatory infiltrate, and thickened bowel walls.
Treatment with propolis moderately reduced the inflammatory response, decreased the number of cysts and abscesses, inhibited epithelial proliferation, and increased the number of goblet cells.
The anti-inflammatory activity of the propolis SLNC 106 extract was confirmed by the reductions in both the inflammatory infiltrate and the number of cysts and abscesses in the colon mucosa.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gonçalves, Cely Cristina Martins& Hernandes, Luzmarina& Bersani-Amado, Ciomar Aparecida& Franco, Selma Lucy& Silva, Joaquim Felipe de Souza& Natali, Maria Raquel Marçal. 2013. Use of Propolis Hydroalcoholic Extract to Treat Colitis Experimentally Induced in Rats by 2,4,6-Trinitrobenzenesulfonic Acid. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-503570
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gonçalves, Cely Cristina Martins…[et al.]. Use of Propolis Hydroalcoholic Extract to Treat Colitis Experimentally Induced in Rats by 2,4,6-Trinitrobenzenesulfonic Acid. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-503570
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gonçalves, Cely Cristina Martins& Hernandes, Luzmarina& Bersani-Amado, Ciomar Aparecida& Franco, Selma Lucy& Silva, Joaquim Felipe de Souza& Natali, Maria Raquel Marçal. Use of Propolis Hydroalcoholic Extract to Treat Colitis Experimentally Induced in Rats by 2,4,6-Trinitrobenzenesulfonic Acid. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-503570
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-503570
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر