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Use of Propolis Hydroalcoholic Extract to Treat Colitis Experimentally Induced in Rats by 2,4,6-Trinitrobenzenesulfonic Acid
Joint Authors
Franco, Selma Lucy
Hernandes, Luzmarina
Gonçalves, Cely Cristina Martins
Natali, Maria Raquel Marçal
Silva, Joaquim Felipe de Souza
Bersani-Amado, Ciomar Aparecida
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
This study focused on the therapeutic effect of a propolis SLNC 106PI extract on experimental colitis.
Wistar adult rats received 0.8 mL rectal dose of one of the following solutions: saline (group S), 20 mg TNBS in 50% ethanol (group TNBS), 20 mg TNBS in 50% ethanol and propolis extract in saline (group TNBS-P), propolis extract in saline (group SP), and 20 mg TNBS in 50% ethanol and 50 mg/kg mesalazine (group TNBS-M).
The animals were euthanized 7 or 14 days after the colitis induction.
Samples of the distal colon were harvested for the analysis of myeloperoxidase (MPO) enzyme activity and for morphometric analysis in paraffin-embedded histological sections with hematoxylin-eosin or histochemical staining.
The animals treated with TNBS exhibited the typical clinical signs of colitis.
Increased MPO activity confirmed the presence of inflammation.
TNBS induced the development of megacolon, ulceration, transmural inflammatory infiltrate, and thickened bowel walls.
Treatment with propolis moderately reduced the inflammatory response, decreased the number of cysts and abscesses, inhibited epithelial proliferation, and increased the number of goblet cells.
The anti-inflammatory activity of the propolis SLNC 106 extract was confirmed by the reductions in both the inflammatory infiltrate and the number of cysts and abscesses in the colon mucosa.
American Psychological Association (APA)
Gonçalves, Cely Cristina Martins& Hernandes, Luzmarina& Bersani-Amado, Ciomar Aparecida& Franco, Selma Lucy& Silva, Joaquim Felipe de Souza& Natali, Maria Raquel Marçal. 2013. Use of Propolis Hydroalcoholic Extract to Treat Colitis Experimentally Induced in Rats by 2,4,6-Trinitrobenzenesulfonic Acid. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-503570
Modern Language Association (MLA)
Gonçalves, Cely Cristina Martins…[et al.]. Use of Propolis Hydroalcoholic Extract to Treat Colitis Experimentally Induced in Rats by 2,4,6-Trinitrobenzenesulfonic Acid. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-503570
American Medical Association (AMA)
Gonçalves, Cely Cristina Martins& Hernandes, Luzmarina& Bersani-Amado, Ciomar Aparecida& Franco, Selma Lucy& Silva, Joaquim Felipe de Souza& Natali, Maria Raquel Marçal. Use of Propolis Hydroalcoholic Extract to Treat Colitis Experimentally Induced in Rats by 2,4,6-Trinitrobenzenesulfonic Acid. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-503570
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503570