![](/images/graphics-bg.png)
The Effect of Rilonacept versus Placebo on Health-Related Quality of Life in Patients with Poorly Controlled Familial Mediterranean Fever
المؤلفون المشاركون
Samuels, Jonathan
Weisman, Michael H.
Hajj-Ali, Rula
Hashkes, Philip J.
Spalding, Steven J.
Barron, Karyl S.
Reiff, Andreas O.
Huang, Bin
Wright, Dowain
Pashinian, Noune
Giannini, Edward H.
Lovell, Daniel J.
Johnson, Anne
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-15
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
To examine the effect of rilonacept on the health-related quality of life (HRQoL) in patients with poorly controlled familial Mediterranean fever (FMF).
Methods.
As part of a randomized, double-blinded trial comparing rilonacept and placebo for the treatment of FMF, patients/parents completed the modified Child Health Questionnaire (CHQ) at baseline, and at the start and end of each of 4 treatment courses, 2 each with rilonacept and placebo.
Results.
Fourteen subjects were randomized; mean age was 24.4 ± 11.8 years.
At baseline the physical HRQoL score was significantly less (24.2 ± 49.5) but the psychosocial score was similar to the population norm (49.5 ± 10.0).
There were significant improvements in most HRQoL concepts after rilonacept but not placebo.
Significant differences between rilonacept and placebo were found in the physical (33.7 ± 16.4 versus 23.7 ± 14.5, P=0.021) but not psychosocial scores (51.4 ± 10.3 versus 49.8 ± 12.4, P=0.42).
The physical HRQoL was significantly impacted by the treatment effect and patient global assessment.
Conclusion.
Treatment with rilonacept had a beneficial effect on the physical HRQoL in patients with poorly controlled FMF and was also significantly related to the patient global assessment.
This trial is registered with ClinicalTrials.gov Identifier NCT00582907.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hashkes, Philip J.& Spalding, Steven J.& Hajj-Ali, Rula& Giannini, Edward H.& Johnson, Anne& Barron, Karyl S.…[et al.]. 2014. The Effect of Rilonacept versus Placebo on Health-Related Quality of Life in Patients with Poorly Controlled Familial Mediterranean Fever. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-503662
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hashkes, Philip J.…[et al.]. The Effect of Rilonacept versus Placebo on Health-Related Quality of Life in Patients with Poorly Controlled Familial Mediterranean Fever. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-503662
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hashkes, Philip J.& Spalding, Steven J.& Hajj-Ali, Rula& Giannini, Edward H.& Johnson, Anne& Barron, Karyl S.…[et al.]. The Effect of Rilonacept versus Placebo on Health-Related Quality of Life in Patients with Poorly Controlled Familial Mediterranean Fever. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-503662
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-503662
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)