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The Effect of Rilonacept versus Placebo on Health-Related Quality of Life in Patients with Poorly Controlled Familial Mediterranean Fever
Joint Authors
Samuels, Jonathan
Weisman, Michael H.
Hajj-Ali, Rula
Hashkes, Philip J.
Spalding, Steven J.
Barron, Karyl S.
Reiff, Andreas O.
Huang, Bin
Wright, Dowain
Pashinian, Noune
Giannini, Edward H.
Lovell, Daniel J.
Johnson, Anne
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To examine the effect of rilonacept on the health-related quality of life (HRQoL) in patients with poorly controlled familial Mediterranean fever (FMF).
Methods.
As part of a randomized, double-blinded trial comparing rilonacept and placebo for the treatment of FMF, patients/parents completed the modified Child Health Questionnaire (CHQ) at baseline, and at the start and end of each of 4 treatment courses, 2 each with rilonacept and placebo.
Results.
Fourteen subjects were randomized; mean age was 24.4 ± 11.8 years.
At baseline the physical HRQoL score was significantly less (24.2 ± 49.5) but the psychosocial score was similar to the population norm (49.5 ± 10.0).
There were significant improvements in most HRQoL concepts after rilonacept but not placebo.
Significant differences between rilonacept and placebo were found in the physical (33.7 ± 16.4 versus 23.7 ± 14.5, P=0.021) but not psychosocial scores (51.4 ± 10.3 versus 49.8 ± 12.4, P=0.42).
The physical HRQoL was significantly impacted by the treatment effect and patient global assessment.
Conclusion.
Treatment with rilonacept had a beneficial effect on the physical HRQoL in patients with poorly controlled FMF and was also significantly related to the patient global assessment.
This trial is registered with ClinicalTrials.gov Identifier NCT00582907.
American Psychological Association (APA)
Hashkes, Philip J.& Spalding, Steven J.& Hajj-Ali, Rula& Giannini, Edward H.& Johnson, Anne& Barron, Karyl S.…[et al.]. 2014. The Effect of Rilonacept versus Placebo on Health-Related Quality of Life in Patients with Poorly Controlled Familial Mediterranean Fever. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-503662
Modern Language Association (MLA)
Hashkes, Philip J.…[et al.]. The Effect of Rilonacept versus Placebo on Health-Related Quality of Life in Patients with Poorly Controlled Familial Mediterranean Fever. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-503662
American Medical Association (AMA)
Hashkes, Philip J.& Spalding, Steven J.& Hajj-Ali, Rula& Giannini, Edward H.& Johnson, Anne& Barron, Karyl S.…[et al.]. The Effect of Rilonacept versus Placebo on Health-Related Quality of Life in Patients with Poorly Controlled Familial Mediterranean Fever. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-503662
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503662