Early Stages of wewe walwal Mouse Hair Morphogenesis : Light and Fluorescent Microscopy of the Whole-Mount Epidermis
المؤلفون المشاركون
Rippa, Alexandra
Vorotelyak, Ekaterina
Vasiliev, Andrey
Terskikh, Vasily
Popenko, Vladimir
Leonova, Olga
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-03
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
In adult skin, hair follicles cyclically self-renew in a manner that recapitulates embryonic hair follicle morphogenesis.
The most common pathology of hair in adults is alopecia, which is hair loss to different extent.
There are a number of murine models of alopecia including spontaneous mutations.
In the present study, we worked with double homozygous we/we wal/wal mice which demonstrate symptoms closely resembling human alopecia.
Using whole-mount preparations of epidermis of E18.5 embryos we show that hair follicle defects can be revealed as early as during embryonic morphogenesis in these mutants.
The number of hair follicles was reduced almost 1.5-fold in mutant skin.
The shape of the early stage small follicles was altered in mutant animals as compared to control ones.
Additionally, follicles of mutant embryos were wider at the point of conjunction with interfollicular epidermis.
We believe that the mutant mice studied represent a fascinating model to address the problem of hair loss.
We demonstrated alterations in the morphogenesis of embryonic hair follicle in we/we wal/wal double homozygous mice developing alopecia postnatally.
We suppose that incorrect morphogenesis of hair follicles during embryogenesis is closely related to alopecia in the adult life.
Unveiling the mechanisms involved in altered embryogenesis may elucidate the pathogenesis of alopecia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rippa, Alexandra& Leonova, Olga& Popenko, Vladimir& Vasiliev, Andrey& Terskikh, Vasily& Vorotelyak, Ekaterina. 2014. Early Stages of wewe walwal Mouse Hair Morphogenesis : Light and Fluorescent Microscopy of the Whole-Mount Epidermis. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-503776
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rippa, Alexandra…[et al.]. Early Stages of wewe walwal Mouse Hair Morphogenesis : Light and Fluorescent Microscopy of the Whole-Mount Epidermis. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-503776
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rippa, Alexandra& Leonova, Olga& Popenko, Vladimir& Vasiliev, Andrey& Terskikh, Vasily& Vorotelyak, Ekaterina. Early Stages of wewe walwal Mouse Hair Morphogenesis : Light and Fluorescent Microscopy of the Whole-Mount Epidermis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-503776
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-503776
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر