Early Stages of wewe walwal Mouse Hair Morphogenesis : Light and Fluorescent Microscopy of the Whole-Mount Epidermis
Joint Authors
Rippa, Alexandra
Vorotelyak, Ekaterina
Vasiliev, Andrey
Terskikh, Vasily
Popenko, Vladimir
Leonova, Olga
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
In adult skin, hair follicles cyclically self-renew in a manner that recapitulates embryonic hair follicle morphogenesis.
The most common pathology of hair in adults is alopecia, which is hair loss to different extent.
There are a number of murine models of alopecia including spontaneous mutations.
In the present study, we worked with double homozygous we/we wal/wal mice which demonstrate symptoms closely resembling human alopecia.
Using whole-mount preparations of epidermis of E18.5 embryos we show that hair follicle defects can be revealed as early as during embryonic morphogenesis in these mutants.
The number of hair follicles was reduced almost 1.5-fold in mutant skin.
The shape of the early stage small follicles was altered in mutant animals as compared to control ones.
Additionally, follicles of mutant embryos were wider at the point of conjunction with interfollicular epidermis.
We believe that the mutant mice studied represent a fascinating model to address the problem of hair loss.
We demonstrated alterations in the morphogenesis of embryonic hair follicle in we/we wal/wal double homozygous mice developing alopecia postnatally.
We suppose that incorrect morphogenesis of hair follicles during embryogenesis is closely related to alopecia in the adult life.
Unveiling the mechanisms involved in altered embryogenesis may elucidate the pathogenesis of alopecia.
American Psychological Association (APA)
Rippa, Alexandra& Leonova, Olga& Popenko, Vladimir& Vasiliev, Andrey& Terskikh, Vasily& Vorotelyak, Ekaterina. 2014. Early Stages of wewe walwal Mouse Hair Morphogenesis : Light and Fluorescent Microscopy of the Whole-Mount Epidermis. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-503776
Modern Language Association (MLA)
Rippa, Alexandra…[et al.]. Early Stages of wewe walwal Mouse Hair Morphogenesis : Light and Fluorescent Microscopy of the Whole-Mount Epidermis. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-503776
American Medical Association (AMA)
Rippa, Alexandra& Leonova, Olga& Popenko, Vladimir& Vasiliev, Andrey& Terskikh, Vasily& Vorotelyak, Ekaterina. Early Stages of wewe walwal Mouse Hair Morphogenesis : Light and Fluorescent Microscopy of the Whole-Mount Epidermis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-503776
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503776