Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro
المؤلفون المشاركون
Cheng, Ti-Sheng
Wu, Chin-Chung
Chang, Fang-Rong
Tsai, Yu-Chi
Wong, Teng-Song
Kuo, Ching-Ying
Chiang, Shang-Yu
Wu, Yang-Chang
Wang, Hui-Chun
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-16
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Liriope spicata is a well-known herb in traditional Chinese medicine, and its root has been clinically demonstrated to be effective in the treatment of metabolic and neural disorders.
The constituents isolated from Liriope have also recently been shown to possess anticancer activity, although the mechanism of which remains largely unknown.
Here, we illustrate the anticancer activity of LPRP-9, one of the active fractions we fractionated from the Liriope platyphylla root part (LPRP) extract.
Treatment with LPRP-9 significantly inhibited proliferation of cancer cell lines MCF-7 and Huh-7 and down-regulated the phosphorylation of AKT.
LPRP-9 also activates the stress-activated MPAK, JNK, p38 pathways, the p53 cell-cycle checkpoint pathway, and a series of caspase cascades while downregulating expression of antiapoptotic factors Bcl-2, Bcl-XL, and survivin.
Such activities strongly suggest a role for LPRP-9 in apoptosis and autophagy.
We further purified and identified the compound (−)-Liriopein B from LPRP-9, which is capable of inhibiting AKT phosphorylation at low concentration.
The overall result highlights the anticancer property of LPRP-9, suggests its mechanism for inhibition of proliferation and promotion of cell death for cancer cells via regulation of multitarget pathways, and denotes the importance of purifying components of fraction LPRP-9 to aid cancer therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Hui-Chun& Wu, Chin-Chung& Cheng, Ti-Sheng& Kuo, Ching-Ying& Tsai, Yu-Chi& Chiang, Shang-Yu…[et al.]. 2013. Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-503870
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Hui-Chun…[et al.]. Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-503870
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Hui-Chun& Wu, Chin-Chung& Cheng, Ti-Sheng& Kuo, Ching-Ying& Tsai, Yu-Chi& Chiang, Shang-Yu…[et al.]. Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-503870
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-503870
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر