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Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro
Joint Authors
Cheng, Ti-Sheng
Wu, Chin-Chung
Chang, Fang-Rong
Tsai, Yu-Chi
Wong, Teng-Song
Kuo, Ching-Ying
Chiang, Shang-Yu
Wu, Yang-Chang
Wang, Hui-Chun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Liriope spicata is a well-known herb in traditional Chinese medicine, and its root has been clinically demonstrated to be effective in the treatment of metabolic and neural disorders.
The constituents isolated from Liriope have also recently been shown to possess anticancer activity, although the mechanism of which remains largely unknown.
Here, we illustrate the anticancer activity of LPRP-9, one of the active fractions we fractionated from the Liriope platyphylla root part (LPRP) extract.
Treatment with LPRP-9 significantly inhibited proliferation of cancer cell lines MCF-7 and Huh-7 and down-regulated the phosphorylation of AKT.
LPRP-9 also activates the stress-activated MPAK, JNK, p38 pathways, the p53 cell-cycle checkpoint pathway, and a series of caspase cascades while downregulating expression of antiapoptotic factors Bcl-2, Bcl-XL, and survivin.
Such activities strongly suggest a role for LPRP-9 in apoptosis and autophagy.
We further purified and identified the compound (−)-Liriopein B from LPRP-9, which is capable of inhibiting AKT phosphorylation at low concentration.
The overall result highlights the anticancer property of LPRP-9, suggests its mechanism for inhibition of proliferation and promotion of cell death for cancer cells via regulation of multitarget pathways, and denotes the importance of purifying components of fraction LPRP-9 to aid cancer therapy.
American Psychological Association (APA)
Wang, Hui-Chun& Wu, Chin-Chung& Cheng, Ti-Sheng& Kuo, Ching-Ying& Tsai, Yu-Chi& Chiang, Shang-Yu…[et al.]. 2013. Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-503870
Modern Language Association (MLA)
Wang, Hui-Chun…[et al.]. Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-503870
American Medical Association (AMA)
Wang, Hui-Chun& Wu, Chin-Chung& Cheng, Ti-Sheng& Kuo, Ching-Ying& Tsai, Yu-Chi& Chiang, Shang-Yu…[et al.]. Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-503870
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503870