![](/images/graphics-bg.png)
Carcinomas of Distal Fallopian Tube and Their Association with Tubal Intraepithelial Carcinoma : Do They Share a Common “Precursor” Lesion? Loss of Heterozygosity and Immunohistochemical Analysis Using PAX 2, WT-1, and P53 Markers
المؤلفون المشاركون
Nikiforova, Marina
Chivukula, Mamatha
McManus, Kim
Carter, Gloria
Mantha, Geetha
Edwards, Robert
Niemeier, Leo A.
المصدر
ISRN Obstetrics and Gynecology
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-12-15
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
As the role of distal fallopian tube as organ of serous carcinogenesis is emerging, additional literature on the role of tubal intraepithelial carcinoma (TIC) as a precursor lesion in a subset of primary peritoneal serous carcinomas (PPSC is emerging as well.
TIC although fallopian tube in origin can be genetically related to ovarian/peritoneal carcinomas.
The role of PAX2 in primary fallopian tube carcinomas (PFTC)/PPSC is yet to be defined.
The aim of our study was to understand if the biologic properties of tumors arising in the distal fallopian tube that remain as PFTC are different when they seed on to the peritoneal surface (PPSC).
A panel of 6 polymorphic microsatellite markers corresponding to p53, PAX2, and WT1 tumor suppressor genes were studied.
Invasive carcinomas as well as TIC arising in the distal fallopian tube when remain as PFTC appears to exhibit different LOH patterns in comparison to PPSC.
PAX 2 LOH patterns might represent a “hidden PAX 2 signature” analogous to p53 signatures.
PAX 2 might be an emerging marker for detection of early serous carcinomas particularly in BRCA + women.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chivukula, Mamatha& Niemeier, Leo A.& Edwards, Robert& Nikiforova, Marina& Mantha, Geetha& McManus, Kim…[et al.]. 2010. Carcinomas of Distal Fallopian Tube and Their Association with Tubal Intraepithelial Carcinoma : Do They Share a Common “Precursor” Lesion? Loss of Heterozygosity and Immunohistochemical Analysis Using PAX 2, WT-1, and P53 Markers. ISRN Obstetrics and Gynecology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-503933
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chivukula, Mamatha…[et al.]. Carcinomas of Distal Fallopian Tube and Their Association with Tubal Intraepithelial Carcinoma : Do They Share a Common “Precursor” Lesion? Loss of Heterozygosity and Immunohistochemical Analysis Using PAX 2, WT-1, and P53 Markers. ISRN Obstetrics and Gynecology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-503933
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chivukula, Mamatha& Niemeier, Leo A.& Edwards, Robert& Nikiforova, Marina& Mantha, Geetha& McManus, Kim…[et al.]. Carcinomas of Distal Fallopian Tube and Their Association with Tubal Intraepithelial Carcinoma : Do They Share a Common “Precursor” Lesion? Loss of Heterozygosity and Immunohistochemical Analysis Using PAX 2, WT-1, and P53 Markers. ISRN Obstetrics and Gynecology. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-503933
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-503933
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)