![](/images/graphics-bg.png)
Carcinomas of Distal Fallopian Tube and Their Association with Tubal Intraepithelial Carcinoma : Do They Share a Common “Precursor” Lesion? Loss of Heterozygosity and Immunohistochemical Analysis Using PAX 2, WT-1, and P53 Markers
Joint Authors
Nikiforova, Marina
Chivukula, Mamatha
McManus, Kim
Carter, Gloria
Mantha, Geetha
Edwards, Robert
Niemeier, Leo A.
Source
ISRN Obstetrics and Gynecology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
As the role of distal fallopian tube as organ of serous carcinogenesis is emerging, additional literature on the role of tubal intraepithelial carcinoma (TIC) as a precursor lesion in a subset of primary peritoneal serous carcinomas (PPSC is emerging as well.
TIC although fallopian tube in origin can be genetically related to ovarian/peritoneal carcinomas.
The role of PAX2 in primary fallopian tube carcinomas (PFTC)/PPSC is yet to be defined.
The aim of our study was to understand if the biologic properties of tumors arising in the distal fallopian tube that remain as PFTC are different when they seed on to the peritoneal surface (PPSC).
A panel of 6 polymorphic microsatellite markers corresponding to p53, PAX2, and WT1 tumor suppressor genes were studied.
Invasive carcinomas as well as TIC arising in the distal fallopian tube when remain as PFTC appears to exhibit different LOH patterns in comparison to PPSC.
PAX 2 LOH patterns might represent a “hidden PAX 2 signature” analogous to p53 signatures.
PAX 2 might be an emerging marker for detection of early serous carcinomas particularly in BRCA + women.
American Psychological Association (APA)
Chivukula, Mamatha& Niemeier, Leo A.& Edwards, Robert& Nikiforova, Marina& Mantha, Geetha& McManus, Kim…[et al.]. 2010. Carcinomas of Distal Fallopian Tube and Their Association with Tubal Intraepithelial Carcinoma : Do They Share a Common “Precursor” Lesion? Loss of Heterozygosity and Immunohistochemical Analysis Using PAX 2, WT-1, and P53 Markers. ISRN Obstetrics and Gynecology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-503933
Modern Language Association (MLA)
Chivukula, Mamatha…[et al.]. Carcinomas of Distal Fallopian Tube and Their Association with Tubal Intraepithelial Carcinoma : Do They Share a Common “Precursor” Lesion? Loss of Heterozygosity and Immunohistochemical Analysis Using PAX 2, WT-1, and P53 Markers. ISRN Obstetrics and Gynecology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-503933
American Medical Association (AMA)
Chivukula, Mamatha& Niemeier, Leo A.& Edwards, Robert& Nikiforova, Marina& Mantha, Geetha& McManus, Kim…[et al.]. Carcinomas of Distal Fallopian Tube and Their Association with Tubal Intraepithelial Carcinoma : Do They Share a Common “Precursor” Lesion? Loss of Heterozygosity and Immunohistochemical Analysis Using PAX 2, WT-1, and P53 Markers. ISRN Obstetrics and Gynecology. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-503933
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503933