Transient Limb Ischemia Alters Serum Protein Expression in Healthy Volunteers : Complement C3 and Vitronectin May Be Involved in Organ Protection Induced by Remote Ischemic Preconditioning
المؤلفون المشاركون
Jin, San-Qing
Zhao, Yang
Pang, Ting
Pan, San-Qiang
Zhang, Nan-Rong
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-02
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
The protective mechanism underlying remote ischemic preconditioning (RIPC) is unclear.
This study aims to verify whether the protein expression profile in the serum could be altered by RIPC and to detect potential protein mediators.
Transient limb ischemia consisting of three cycles of 5-min ischemia followed by 5-min reperfusion was performed on sixty healthy volunteers.
Serum samples were collected at 30 min before transient limb ischemia and at 1 hour (h), 3 h, 8 h, 24 h, and 48 h after completion of three cycles.
Changes in the serum protein profile were analyzed by two-dimensional gel electrophoresis and proteins were identified by MALDI-TOF/TOF mass spectrometry.
Fourteen differentially expressed proteins were identified and, respectively, involved in immune system, lipid binding and metabolism, apoptosis, and blood coagulation.
Complement C3, vitronectin, and apolipoprotein A-I were further confirmed by western blotting, and the results showed that their contents decreased significantly after transient limb ischemia.
It is concluded that transient limb ischemia alters the serum protein expression profile in human being, and that reduction of serum contents of complement C3 and vitronectin may represent an important part of the mechanism whereby RIPC confers its protection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pang, Ting& Zhao, Yang& Zhang, Nan-Rong& Jin, San-Qing& Pan, San-Qiang. 2013. Transient Limb Ischemia Alters Serum Protein Expression in Healthy Volunteers : Complement C3 and Vitronectin May Be Involved in Organ Protection Induced by Remote Ischemic Preconditioning. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-503960
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pang, Ting…[et al.]. Transient Limb Ischemia Alters Serum Protein Expression in Healthy Volunteers : Complement C3 and Vitronectin May Be Involved in Organ Protection Induced by Remote Ischemic Preconditioning. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-503960
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pang, Ting& Zhao, Yang& Zhang, Nan-Rong& Jin, San-Qing& Pan, San-Qiang. Transient Limb Ischemia Alters Serum Protein Expression in Healthy Volunteers : Complement C3 and Vitronectin May Be Involved in Organ Protection Induced by Remote Ischemic Preconditioning. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-503960
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-503960
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر