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Squamous Cell Carcinoma of the Pancreas in a Patient with Germline BRCA2 Mutation-Response to Neoadjuvant Radiochemotherapy
المؤلفون المشاركون
Ortmann, Monika
Büttner, Reinhard
Schultheis, Anne M.
Schildhaus, Hans-Ulrich
Markiefka, Birgid
Nguyen, Gia Phuong
Kruis, Wolfgang
المصدر
Case Reports in Oncological Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-18
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Primary squamous cell carcinoma of the pancreas is a rare malignant neoplasia, accounting for approximately 0.5–2% of all malignant pancreatic tumors.
These lesions are characterized by poor prognosis.
Here we report on a case of a 57-year-old female patient with known BRCA2 germline mutation presenting with primary squamous cell carcinoma of the pancreas as the only malignancy.
The tumor was locally advanced at the first presentation but responded almost completely to neoadjuvant radio-chemotherapy.
Our case highlights the facts (i) that pancreatic carcinomas belong to the tumor spectrum of patients with the BRCA2-associated hereditary breast and ovarian cancer syndrome (HBOC) and (ii) that tumors of the pancreas can represent the first or even the only manifestation of HBOC.
Furthermore, this case of a nonkeratinizing squamous cell carcinoma indicates that HBOC-associated carcinomas of the pancreas might be characterized by a broader morphological spectrum than was previously thought.
Since BRCA mutations cause deficiency of DNA double-strand breakage repair in tumors, neoadjuvant treatment regimens might become a reasonable option in HBOC-associated pancreatic carcinomas.
To our knowledge, this is the first reported case of a primary pancreatic squamous cell carcinoma in a patient with this particular genetic background of BRCA2-associated HBOC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Schultheis, Anne M.& Nguyen, Gia Phuong& Ortmann, Monika& Kruis, Wolfgang& Büttner, Reinhard& Schildhaus, Hans-Ulrich…[et al.]. 2014. Squamous Cell Carcinoma of the Pancreas in a Patient with Germline BRCA2 Mutation-Response to Neoadjuvant Radiochemotherapy. Case Reports in Oncological Medicine،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-504096
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Schultheis, Anne M.…[et al.]. Squamous Cell Carcinoma of the Pancreas in a Patient with Germline BRCA2 Mutation-Response to Neoadjuvant Radiochemotherapy. Case Reports in Oncological Medicine No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-504096
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Schultheis, Anne M.& Nguyen, Gia Phuong& Ortmann, Monika& Kruis, Wolfgang& Büttner, Reinhard& Schildhaus, Hans-Ulrich…[et al.]. Squamous Cell Carcinoma of the Pancreas in a Patient with Germline BRCA2 Mutation-Response to Neoadjuvant Radiochemotherapy. Case Reports in Oncological Medicine. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-504096
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-504096
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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