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Squamous Cell Carcinoma of the Pancreas in a Patient with Germline BRCA2 Mutation-Response to Neoadjuvant Radiochemotherapy
Joint Authors
Ortmann, Monika
Büttner, Reinhard
Schultheis, Anne M.
Schildhaus, Hans-Ulrich
Markiefka, Birgid
Nguyen, Gia Phuong
Kruis, Wolfgang
Source
Case Reports in Oncological Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-18
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Primary squamous cell carcinoma of the pancreas is a rare malignant neoplasia, accounting for approximately 0.5–2% of all malignant pancreatic tumors.
These lesions are characterized by poor prognosis.
Here we report on a case of a 57-year-old female patient with known BRCA2 germline mutation presenting with primary squamous cell carcinoma of the pancreas as the only malignancy.
The tumor was locally advanced at the first presentation but responded almost completely to neoadjuvant radio-chemotherapy.
Our case highlights the facts (i) that pancreatic carcinomas belong to the tumor spectrum of patients with the BRCA2-associated hereditary breast and ovarian cancer syndrome (HBOC) and (ii) that tumors of the pancreas can represent the first or even the only manifestation of HBOC.
Furthermore, this case of a nonkeratinizing squamous cell carcinoma indicates that HBOC-associated carcinomas of the pancreas might be characterized by a broader morphological spectrum than was previously thought.
Since BRCA mutations cause deficiency of DNA double-strand breakage repair in tumors, neoadjuvant treatment regimens might become a reasonable option in HBOC-associated pancreatic carcinomas.
To our knowledge, this is the first reported case of a primary pancreatic squamous cell carcinoma in a patient with this particular genetic background of BRCA2-associated HBOC.
American Psychological Association (APA)
Schultheis, Anne M.& Nguyen, Gia Phuong& Ortmann, Monika& Kruis, Wolfgang& Büttner, Reinhard& Schildhaus, Hans-Ulrich…[et al.]. 2014. Squamous Cell Carcinoma of the Pancreas in a Patient with Germline BRCA2 Mutation-Response to Neoadjuvant Radiochemotherapy. Case Reports in Oncological Medicine،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-504096
Modern Language Association (MLA)
Schultheis, Anne M.…[et al.]. Squamous Cell Carcinoma of the Pancreas in a Patient with Germline BRCA2 Mutation-Response to Neoadjuvant Radiochemotherapy. Case Reports in Oncological Medicine No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-504096
American Medical Association (AMA)
Schultheis, Anne M.& Nguyen, Gia Phuong& Ortmann, Monika& Kruis, Wolfgang& Büttner, Reinhard& Schildhaus, Hans-Ulrich…[et al.]. Squamous Cell Carcinoma of the Pancreas in a Patient with Germline BRCA2 Mutation-Response to Neoadjuvant Radiochemotherapy. Case Reports in Oncological Medicine. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-504096
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504096