Differentiated Evaluation of Extract-Specific Evidence on Cimicifuga racemosa's Efficacy and Safety for Climacteric Complaints
المؤلفون المشاركون
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-21، 21ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-25
دولة النشر
مصر
عدد الصفحات
21
التخصصات الرئيسية
الملخص EN
Past reviews on Cimicifuga racemosa (CR) without differentiation between extracts, quality, and indication altogether led to inconsistent data.
Therefore, for the first time, we meet the requirements of the system's logic of evidence-based phytotherapy by taking into consideration extracts, pharmaceutical quality (reflected in a regulatory status as medicinal product), and indication.
A literature search for clinical studies examining CR's efficacy and safety for menopausal complaints was conducted.
The results were sorted by type of extract, regulatory status, and indication.
Accordingly, Oxford Levels of Evidence (LOE) and Grades of Recommendation (GR) were determined.
CR extracts demonstrated a good to very good safety in general, on estrogen-sensitive organs and the liver.
However, only registered CR medicinal products were able to prove their efficacy.
Best evidence was provided by the isopropanolic CR extract (iCR): the multitude of studies including more than 11,000 patients demonstrated consistent confirmatory evidence of LOE 1b (LOE 1a for safety) leading to GR A.
The studies on the ethanolic extract BNO 1055 including more than 500 patients showed exploratory evidence of LOE 2b resulting in GR B.
A positive benefit-risk profile is stated and limited to Cimicifuga racemosa products holding a marketing authorisation for treating climacteric complaints.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Beer, Andre-Michael& Neff, A.. 2013. Differentiated Evaluation of Extract-Specific Evidence on Cimicifuga racemosa's Efficacy and Safety for Climacteric Complaints. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-21.
https://search.emarefa.net/detail/BIM-504105
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Beer, Andre-Michael& Neff, A.. Differentiated Evaluation of Extract-Specific Evidence on Cimicifuga racemosa's Efficacy and Safety for Climacteric Complaints. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-21.
https://search.emarefa.net/detail/BIM-504105
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Beer, Andre-Michael& Neff, A.. Differentiated Evaluation of Extract-Specific Evidence on Cimicifuga racemosa's Efficacy and Safety for Climacteric Complaints. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-21.
https://search.emarefa.net/detail/BIM-504105
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-504105
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر