Differentiated Evaluation of Extract-Specific Evidence on Cimicifuga racemosa's Efficacy and Safety for Climacteric Complaints
Joint Authors
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-25
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Past reviews on Cimicifuga racemosa (CR) without differentiation between extracts, quality, and indication altogether led to inconsistent data.
Therefore, for the first time, we meet the requirements of the system's logic of evidence-based phytotherapy by taking into consideration extracts, pharmaceutical quality (reflected in a regulatory status as medicinal product), and indication.
A literature search for clinical studies examining CR's efficacy and safety for menopausal complaints was conducted.
The results were sorted by type of extract, regulatory status, and indication.
Accordingly, Oxford Levels of Evidence (LOE) and Grades of Recommendation (GR) were determined.
CR extracts demonstrated a good to very good safety in general, on estrogen-sensitive organs and the liver.
However, only registered CR medicinal products were able to prove their efficacy.
Best evidence was provided by the isopropanolic CR extract (iCR): the multitude of studies including more than 11,000 patients demonstrated consistent confirmatory evidence of LOE 1b (LOE 1a for safety) leading to GR A.
The studies on the ethanolic extract BNO 1055 including more than 500 patients showed exploratory evidence of LOE 2b resulting in GR B.
A positive benefit-risk profile is stated and limited to Cimicifuga racemosa products holding a marketing authorisation for treating climacteric complaints.
American Psychological Association (APA)
Beer, Andre-Michael& Neff, A.. 2013. Differentiated Evaluation of Extract-Specific Evidence on Cimicifuga racemosa's Efficacy and Safety for Climacteric Complaints. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-21.
https://search.emarefa.net/detail/BIM-504105
Modern Language Association (MLA)
Beer, Andre-Michael& Neff, A.. Differentiated Evaluation of Extract-Specific Evidence on Cimicifuga racemosa's Efficacy and Safety for Climacteric Complaints. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-21.
https://search.emarefa.net/detail/BIM-504105
American Medical Association (AMA)
Beer, Andre-Michael& Neff, A.. Differentiated Evaluation of Extract-Specific Evidence on Cimicifuga racemosa's Efficacy and Safety for Climacteric Complaints. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-21.
https://search.emarefa.net/detail/BIM-504105
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504105