The Effects of Proresolution of Ellagic Acid in an Experimental Model of Allergic Airway Inflammation
المؤلفون المشاركون
Lazo Chica, Javier Emilio
Roberto da Silva, Paulo
de Freitas Alves, Claudiney
Angeli, Giovanna Natalia
Faccioli, Lúcia Helena
Favarin, Daniely Cornélio
de Paula Rogerio, Alexandre
Lemos de Andrade, Edinéia
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-26
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Asthma is a disease of airway inflammation characterized by airway hyperresponsiveness, eosinophilic inflammation, and hypersecretion of mucus.
Ellagic acid, a compound derived from medicinal plants and fruits, has shown anti-inflammatory activity in several experimental disease models.
We used the classical experimental model, in BALB/c mice, of sensibilization with ovalbumin to determine the effect of ellagic acid (10 mg/kg; oral route) in the resolution of allergic airways response.
Dexamethasone (1 mg/kg; subcutaneous route) was used as a positive control.
The control group consisted of nonimmunized mice that received challenge with ovalbumin.
Ellagic acid and dexamethasone or vehicle (water) were administered before or after intranasal allergen challenge.
Ellagic acid accelerated the resolution of airways inflammation by decreasing total leukocytes and eosinophils numbers in the bronchoalveolar lavage fluid (BALF), the mucus production and lung inflammation in part by reducing IL-5 concentration, eosinophil peroxidase (EPO) activity, and P-selectin expression, but not activator protein 1 (AP-1) and nuclear factor kappa B (NF-κB) pathways.
In addition, ellagic acid enhanced alveolar macrophage phagocytosis of IgG-OVA-coated beads ex vivo, a new proresolving mechanism for the clearance of allergen from the airways.
Together, these findings identify ellagic acid as a potential therapeutic agent for accelerating the resolution of allergic airways inflammation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
de Freitas Alves, Claudiney& Angeli, Giovanna Natalia& Favarin, Daniely Cornélio& Lemos de Andrade, Edinéia& Lazo Chica, Javier Emilio& Faccioli, Lúcia Helena…[et al.]. 2013. The Effects of Proresolution of Ellagic Acid in an Experimental Model of Allergic Airway Inflammation. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-504365
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
de Freitas Alves, Claudiney…[et al.]. The Effects of Proresolution of Ellagic Acid in an Experimental Model of Allergic Airway Inflammation. Mediators of Inflammation No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-504365
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
de Freitas Alves, Claudiney& Angeli, Giovanna Natalia& Favarin, Daniely Cornélio& Lemos de Andrade, Edinéia& Lazo Chica, Javier Emilio& Faccioli, Lúcia Helena…[et al.]. The Effects of Proresolution of Ellagic Acid in an Experimental Model of Allergic Airway Inflammation. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-504365
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-504365
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر