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The Effects of Proresolution of Ellagic Acid in an Experimental Model of Allergic Airway Inflammation
Joint Authors
Lazo Chica, Javier Emilio
Roberto da Silva, Paulo
de Freitas Alves, Claudiney
Angeli, Giovanna Natalia
Faccioli, Lúcia Helena
Favarin, Daniely Cornélio
de Paula Rogerio, Alexandre
Lemos de Andrade, Edinéia
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Asthma is a disease of airway inflammation characterized by airway hyperresponsiveness, eosinophilic inflammation, and hypersecretion of mucus.
Ellagic acid, a compound derived from medicinal plants and fruits, has shown anti-inflammatory activity in several experimental disease models.
We used the classical experimental model, in BALB/c mice, of sensibilization with ovalbumin to determine the effect of ellagic acid (10 mg/kg; oral route) in the resolution of allergic airways response.
Dexamethasone (1 mg/kg; subcutaneous route) was used as a positive control.
The control group consisted of nonimmunized mice that received challenge with ovalbumin.
Ellagic acid and dexamethasone or vehicle (water) were administered before or after intranasal allergen challenge.
Ellagic acid accelerated the resolution of airways inflammation by decreasing total leukocytes and eosinophils numbers in the bronchoalveolar lavage fluid (BALF), the mucus production and lung inflammation in part by reducing IL-5 concentration, eosinophil peroxidase (EPO) activity, and P-selectin expression, but not activator protein 1 (AP-1) and nuclear factor kappa B (NF-κB) pathways.
In addition, ellagic acid enhanced alveolar macrophage phagocytosis of IgG-OVA-coated beads ex vivo, a new proresolving mechanism for the clearance of allergen from the airways.
Together, these findings identify ellagic acid as a potential therapeutic agent for accelerating the resolution of allergic airways inflammation.
American Psychological Association (APA)
de Freitas Alves, Claudiney& Angeli, Giovanna Natalia& Favarin, Daniely Cornélio& Lemos de Andrade, Edinéia& Lazo Chica, Javier Emilio& Faccioli, Lúcia Helena…[et al.]. 2013. The Effects of Proresolution of Ellagic Acid in an Experimental Model of Allergic Airway Inflammation. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-504365
Modern Language Association (MLA)
de Freitas Alves, Claudiney…[et al.]. The Effects of Proresolution of Ellagic Acid in an Experimental Model of Allergic Airway Inflammation. Mediators of Inflammation No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-504365
American Medical Association (AMA)
de Freitas Alves, Claudiney& Angeli, Giovanna Natalia& Favarin, Daniely Cornélio& Lemos de Andrade, Edinéia& Lazo Chica, Javier Emilio& Faccioli, Lúcia Helena…[et al.]. The Effects of Proresolution of Ellagic Acid in an Experimental Model of Allergic Airway Inflammation. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-504365
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504365