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US Pilot Study of Lumbar to Sacral Nerve Rerouting to Restore Voiding and Bowel Function in Spina Bifida : 3-Year Experience
المؤلفون المشاركون
Peters, Kenneth M.
Trock, Gary
Gilmer, Holly
Boura, Judith A.
Nantau, William
Girdler, Benjamin J.
Killinger, Kim A.
Feber, Kevin
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-02
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
To report our experience with creating a skin-central nervous system-bladder reflex arc with intradural lumbar to sacral motor root microanastomosis to restore bladder/bowel function in spina bifida patients.
Methods.
Urinary/bowel changes from baseline to three years were evaluated with questionnaires, voiding diaries, urodynamics (UDS), and renal function studies.
Treatment response was defined as CIC ≤ once/day with stable renal function, voiding efficiency > 50%, and no worsening of motor function.
Results.
Of 13 subjects (9 female, median age 8 years), 3 voided small amounts at baseline, one voided 200 cc (voiding efficiency 32%), 4/13 reported normal bowels, and 2/13 were continent of stool.
Postoperatively, all had transient lower extremity weakness; one developed permanent foot drop.
Over three years, renal function remained stable and mean maximum cystometric capacity (MCC) increased (P=0.0135).
In the 10 that returned at 3 years, 7 were treatment responders and 9 had discontinued antimuscarinics, but most still leaked urine.
Only 2/8 with baseline neurogenic detrusor overactivity (NDO) still had NDO, all 3 with compliance <10 mL/cm H2O had normalized, 7/10 considered their bowels normal, 5/10 were continent of stool, and 8/10 would undergo the procedure again.
Conclusion.
Lumbar to sacral nerve rerouting can improve elimination in spina bifida patients.
This trial is registered with ClinicalTrials.gov NCT00378664.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Peters, Kenneth M.& Gilmer, Holly& Feber, Kevin& Girdler, Benjamin J.& Nantau, William& Trock, Gary…[et al.]. 2014. US Pilot Study of Lumbar to Sacral Nerve Rerouting to Restore Voiding and Bowel Function in Spina Bifida : 3-Year Experience. Advances in Urology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-504367
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Peters, Kenneth M.…[et al.]. US Pilot Study of Lumbar to Sacral Nerve Rerouting to Restore Voiding and Bowel Function in Spina Bifida : 3-Year Experience. Advances in Urology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-504367
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Peters, Kenneth M.& Gilmer, Holly& Feber, Kevin& Girdler, Benjamin J.& Nantau, William& Trock, Gary…[et al.]. US Pilot Study of Lumbar to Sacral Nerve Rerouting to Restore Voiding and Bowel Function in Spina Bifida : 3-Year Experience. Advances in Urology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-504367
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-504367
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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