![](/images/graphics-bg.png)
US Pilot Study of Lumbar to Sacral Nerve Rerouting to Restore Voiding and Bowel Function in Spina Bifida : 3-Year Experience
Joint Authors
Peters, Kenneth M.
Trock, Gary
Gilmer, Holly
Boura, Judith A.
Nantau, William
Girdler, Benjamin J.
Killinger, Kim A.
Feber, Kevin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
To report our experience with creating a skin-central nervous system-bladder reflex arc with intradural lumbar to sacral motor root microanastomosis to restore bladder/bowel function in spina bifida patients.
Methods.
Urinary/bowel changes from baseline to three years were evaluated with questionnaires, voiding diaries, urodynamics (UDS), and renal function studies.
Treatment response was defined as CIC ≤ once/day with stable renal function, voiding efficiency > 50%, and no worsening of motor function.
Results.
Of 13 subjects (9 female, median age 8 years), 3 voided small amounts at baseline, one voided 200 cc (voiding efficiency 32%), 4/13 reported normal bowels, and 2/13 were continent of stool.
Postoperatively, all had transient lower extremity weakness; one developed permanent foot drop.
Over three years, renal function remained stable and mean maximum cystometric capacity (MCC) increased (P=0.0135).
In the 10 that returned at 3 years, 7 were treatment responders and 9 had discontinued antimuscarinics, but most still leaked urine.
Only 2/8 with baseline neurogenic detrusor overactivity (NDO) still had NDO, all 3 with compliance <10 mL/cm H2O had normalized, 7/10 considered their bowels normal, 5/10 were continent of stool, and 8/10 would undergo the procedure again.
Conclusion.
Lumbar to sacral nerve rerouting can improve elimination in spina bifida patients.
This trial is registered with ClinicalTrials.gov NCT00378664.
American Psychological Association (APA)
Peters, Kenneth M.& Gilmer, Holly& Feber, Kevin& Girdler, Benjamin J.& Nantau, William& Trock, Gary…[et al.]. 2014. US Pilot Study of Lumbar to Sacral Nerve Rerouting to Restore Voiding and Bowel Function in Spina Bifida : 3-Year Experience. Advances in Urology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-504367
Modern Language Association (MLA)
Peters, Kenneth M.…[et al.]. US Pilot Study of Lumbar to Sacral Nerve Rerouting to Restore Voiding and Bowel Function in Spina Bifida : 3-Year Experience. Advances in Urology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-504367
American Medical Association (AMA)
Peters, Kenneth M.& Gilmer, Holly& Feber, Kevin& Girdler, Benjamin J.& Nantau, William& Trock, Gary…[et al.]. US Pilot Study of Lumbar to Sacral Nerve Rerouting to Restore Voiding and Bowel Function in Spina Bifida : 3-Year Experience. Advances in Urology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-504367
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504367