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Therapeutic Effect of the Tuber of Alisma orientale on Lipopolysaccharide-Induced Acute Lung Injury
المؤلفون المشاركون
Joo, Myungsoo
Christman, John W.
Kwun, Min Jung
Choi, Jun-Yong
Kim, Kyun Ha
Lee, Yong Gyu
Sadikot, Ruxana T.
Oh, Sei-Ryang
Han, Chang Woo
Ahn, Kyung-Seop
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-25
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Although Alisma orientale, an ethnic herb, has been prescribed for treating various diseases in Asian traditional medicine, experimental evidence to support its therapeutic effects is lacking.
Here, we sought to determine whether A.
orientale has a therapeutic effect on acute lung injury (ALI).
Ethanol extract of the tuber of A.
orientale (EEAO) was prepared and fingerprinted by HPLC for its constituents.
Mice received an intraperitoneal (i.p.) injection of lipopolysaccharide (LPS) for the induction of ALI.
At 2 h after LPS treatment, mice received an intratracheal (i.t.) spraying of various amounts of EEAO to the lung.
Bioluminescence imaging of transgenic NF-κB/luciferase reporter mice shows that i.t.
EEAO posttreatment suppressed lung inflammation.
In similar experiments with C57BL/6 mice, EEAO posttreatment significantly improved lung inflammation, as assessed by H&E staining of lung sections, counting of neutrophils in bronchoalveolar lavage fluid, and semiquantitative RT-PCR analyses of proinflammatory cytokines and Nrf2-dependent genes in the inflamed lungs.
Furthermore, EEAO posttreatment enhanced the survival of mice that received a lethal dose of LPS.
Together, our results provide evidence that A.
orientale has a therapeutic effect on ALI induced by sepsis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Kyun Ha& Kwun, Min Jung& Choi, Jun-Yong& Ahn, Kyung-Seop& Oh, Sei-Ryang& Lee, Yong Gyu…[et al.]. 2013. Therapeutic Effect of the Tuber of Alisma orientale on Lipopolysaccharide-Induced Acute Lung Injury. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-504430
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Kyun Ha…[et al.]. Therapeutic Effect of the Tuber of Alisma orientale on Lipopolysaccharide-Induced Acute Lung Injury. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-504430
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Kyun Ha& Kwun, Min Jung& Choi, Jun-Yong& Ahn, Kyung-Seop& Oh, Sei-Ryang& Lee, Yong Gyu…[et al.]. Therapeutic Effect of the Tuber of Alisma orientale on Lipopolysaccharide-Induced Acute Lung Injury. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-504430
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-504430
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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