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Therapeutic Effect of the Tuber of Alisma orientale on Lipopolysaccharide-Induced Acute Lung Injury
Joint Authors
Joo, Myungsoo
Christman, John W.
Kwun, Min Jung
Choi, Jun-Yong
Kim, Kyun Ha
Lee, Yong Gyu
Sadikot, Ruxana T.
Oh, Sei-Ryang
Han, Chang Woo
Ahn, Kyung-Seop
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Although Alisma orientale, an ethnic herb, has been prescribed for treating various diseases in Asian traditional medicine, experimental evidence to support its therapeutic effects is lacking.
Here, we sought to determine whether A.
orientale has a therapeutic effect on acute lung injury (ALI).
Ethanol extract of the tuber of A.
orientale (EEAO) was prepared and fingerprinted by HPLC for its constituents.
Mice received an intraperitoneal (i.p.) injection of lipopolysaccharide (LPS) for the induction of ALI.
At 2 h after LPS treatment, mice received an intratracheal (i.t.) spraying of various amounts of EEAO to the lung.
Bioluminescence imaging of transgenic NF-κB/luciferase reporter mice shows that i.t.
EEAO posttreatment suppressed lung inflammation.
In similar experiments with C57BL/6 mice, EEAO posttreatment significantly improved lung inflammation, as assessed by H&E staining of lung sections, counting of neutrophils in bronchoalveolar lavage fluid, and semiquantitative RT-PCR analyses of proinflammatory cytokines and Nrf2-dependent genes in the inflamed lungs.
Furthermore, EEAO posttreatment enhanced the survival of mice that received a lethal dose of LPS.
Together, our results provide evidence that A.
orientale has a therapeutic effect on ALI induced by sepsis.
American Psychological Association (APA)
Kim, Kyun Ha& Kwun, Min Jung& Choi, Jun-Yong& Ahn, Kyung-Seop& Oh, Sei-Ryang& Lee, Yong Gyu…[et al.]. 2013. Therapeutic Effect of the Tuber of Alisma orientale on Lipopolysaccharide-Induced Acute Lung Injury. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-504430
Modern Language Association (MLA)
Kim, Kyun Ha…[et al.]. Therapeutic Effect of the Tuber of Alisma orientale on Lipopolysaccharide-Induced Acute Lung Injury. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-504430
American Medical Association (AMA)
Kim, Kyun Ha& Kwun, Min Jung& Choi, Jun-Yong& Ahn, Kyung-Seop& Oh, Sei-Ryang& Lee, Yong Gyu…[et al.]. Therapeutic Effect of the Tuber of Alisma orientale on Lipopolysaccharide-Induced Acute Lung Injury. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-504430
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504430