UPLC Q-TOFMS-Based Metabolic Profiling of Urine Reveals the Novel Antipyretic Mechanisms of Qingkailing Injection in a Rat Model of Yeast-Induced Pyrexia
المؤلفون المشاركون
Bai, Xu
Zhao, Baosheng
Gao, Xiaoyan
Su, Jiankun
Peng, Long
Zhang, Li
Liu, Haiyu
Qiao, Yanjiang
Guo, Mingxing
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-06
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Fever is one of the most common clinical symptoms of many diseases.
Qingkailing (QKL) injection is widely used in China as a clinical emergency medicine due to its good antipyretic effects.
It is a herbal formula which is composed by eight kinds of traditional Chinese medicines (TCM).
As a kind of typical multiple constituents and multiple actions of TCM, it is very difficult to elaborate the antipyretic mechanism by conventional pharmacological method.
Metabonomics technique provides beneficial tool for this challenge.
In this study, an ultra performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC Q-TOF/MS) metabonomics method was developed to explore the changing process of biochemical substances in rats of yeast-induced pyrexia.
Partial least squares discriminate analysis (PLS-DA) was used to distinguish the normal control group, the pyrexia model group, and the pyrexia model group treated by QKL injection.
The potential biomarkers related to pyrexia were confirmed and identified.
MetPA was used to find the possible metabolic pathways.
The results indicated that the antipyretic effect of QKL injection on yeast-induced pyrexia rats was performed by repairing the perturbed metabolism of amino acids.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gao, Xiaoyan& Guo, Mingxing& Peng, Long& Zhao, Baosheng& Su, Jiankun& Liu, Haiyu…[et al.]. 2013. UPLC Q-TOFMS-Based Metabolic Profiling of Urine Reveals the Novel Antipyretic Mechanisms of Qingkailing Injection in a Rat Model of Yeast-Induced Pyrexia. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-504507
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gao, Xiaoyan…[et al.]. UPLC Q-TOFMS-Based Metabolic Profiling of Urine Reveals the Novel Antipyretic Mechanisms of Qingkailing Injection in a Rat Model of Yeast-Induced Pyrexia. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-504507
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gao, Xiaoyan& Guo, Mingxing& Peng, Long& Zhao, Baosheng& Su, Jiankun& Liu, Haiyu…[et al.]. UPLC Q-TOFMS-Based Metabolic Profiling of Urine Reveals the Novel Antipyretic Mechanisms of Qingkailing Injection in a Rat Model of Yeast-Induced Pyrexia. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-504507
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-504507
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر