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UPLC Q-TOFMS-Based Metabolic Profiling of Urine Reveals the Novel Antipyretic Mechanisms of Qingkailing Injection in a Rat Model of Yeast-Induced Pyrexia
Joint Authors
Bai, Xu
Zhao, Baosheng
Gao, Xiaoyan
Su, Jiankun
Peng, Long
Zhang, Li
Liu, Haiyu
Qiao, Yanjiang
Guo, Mingxing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Fever is one of the most common clinical symptoms of many diseases.
Qingkailing (QKL) injection is widely used in China as a clinical emergency medicine due to its good antipyretic effects.
It is a herbal formula which is composed by eight kinds of traditional Chinese medicines (TCM).
As a kind of typical multiple constituents and multiple actions of TCM, it is very difficult to elaborate the antipyretic mechanism by conventional pharmacological method.
Metabonomics technique provides beneficial tool for this challenge.
In this study, an ultra performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC Q-TOF/MS) metabonomics method was developed to explore the changing process of biochemical substances in rats of yeast-induced pyrexia.
Partial least squares discriminate analysis (PLS-DA) was used to distinguish the normal control group, the pyrexia model group, and the pyrexia model group treated by QKL injection.
The potential biomarkers related to pyrexia were confirmed and identified.
MetPA was used to find the possible metabolic pathways.
The results indicated that the antipyretic effect of QKL injection on yeast-induced pyrexia rats was performed by repairing the perturbed metabolism of amino acids.
American Psychological Association (APA)
Gao, Xiaoyan& Guo, Mingxing& Peng, Long& Zhao, Baosheng& Su, Jiankun& Liu, Haiyu…[et al.]. 2013. UPLC Q-TOFMS-Based Metabolic Profiling of Urine Reveals the Novel Antipyretic Mechanisms of Qingkailing Injection in a Rat Model of Yeast-Induced Pyrexia. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-504507
Modern Language Association (MLA)
Gao, Xiaoyan…[et al.]. UPLC Q-TOFMS-Based Metabolic Profiling of Urine Reveals the Novel Antipyretic Mechanisms of Qingkailing Injection in a Rat Model of Yeast-Induced Pyrexia. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-504507
American Medical Association (AMA)
Gao, Xiaoyan& Guo, Mingxing& Peng, Long& Zhao, Baosheng& Su, Jiankun& Liu, Haiyu…[et al.]. UPLC Q-TOFMS-Based Metabolic Profiling of Urine Reveals the Novel Antipyretic Mechanisms of Qingkailing Injection in a Rat Model of Yeast-Induced Pyrexia. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-504507
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504507