Ethanol Exposure Alters Protein Expression in a Mouse Model of Fetal Alcohol Spectrum Disorders
المؤلفون المشاركون
Wang, Mu
Witzmann, Frank A.
Anthony, Bruce
You, Jin-Sam
Ringham, Heather N.
Zhou, Feng C.
Lai, Xianyin
Mason, Stephen
المصدر
International Journal of Proteomics
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-14
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Alcohol exposure during development can result in variable growth retardation and facial dysmorphology known as fetal alcohol spectrum disorders.
Although the mechanisms underlying the disorder are not fully understood, recent progress has been made that alcohol induces aberrant changes in gene expression and in the epigenome of embryos.
To inform the gene and epigenetic changes in alcohol-induced teratology, we used whole-embryo culture to identify the alcohol-signature protein profile of neurulating C6 mice.
Alcohol-treated and control cultures were homogenized, isoelectrically focused, and loaded for 2D gel electrophoresis.
Stained gels were cross matched with analytical software.
We identified 40 differentially expressed protein spots (P<0.01), and 9 spots were selected for LC/MS-MS identification.
Misregulated proteins include serotransferrin, triosephosphate isomerase and ubiquitin-conjugating enzyme E2 N.
Misregulation of serotransferrin and triosephosphate isomerase was confirmed with immunologic analysis.
Alteration of proteins with roles in cellular function, cell cycle, and the ubiquitin-proteasome pathway was induced by alcohol.
Several misregulated proteins interact with effectors of the NF-κB and Myc transcription factor cascades.
Using a whole-embryo culture, we have identified misregulated proteins known to be involved in nervous system development and function.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mason, Stephen& Anthony, Bruce& Lai, Xianyin& Ringham, Heather N.& Wang, Mu& Witzmann, Frank A.…[et al.]. 2012. Ethanol Exposure Alters Protein Expression in a Mouse Model of Fetal Alcohol Spectrum Disorders. International Journal of Proteomics،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-504634
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mason, Stephen…[et al.]. Ethanol Exposure Alters Protein Expression in a Mouse Model of Fetal Alcohol Spectrum Disorders. International Journal of Proteomics No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-504634
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mason, Stephen& Anthony, Bruce& Lai, Xianyin& Ringham, Heather N.& Wang, Mu& Witzmann, Frank A.…[et al.]. Ethanol Exposure Alters Protein Expression in a Mouse Model of Fetal Alcohol Spectrum Disorders. International Journal of Proteomics. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-504634
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-504634
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر