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Diorganotin Complexes of a Thiosemicarbazone, Synthesis : Properties, X-Ray Crystal Structure, and Antiproliferative Activity of Diorganotin Complexes
المؤلفون المشاركون
Ciunik, Zbigniew
Zervou, Maria
Demertzis, Mavroudis A.
Kovala-Demertzi, Dimitra
Wiecek, Joanna
المصدر
Bioinorganic Chemistry and Applications
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-06-20
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The synthesis and spectral characterization of novel diorganotin complexes with 3-hydroxypyridine-2-carbaldehyde thiosemicarbazone, H2L(1), [SnMe2(L)] (2), [SnBu2(L)] (3), and [SnPh2(L)] (4) are reported.
The single-crystal X-ray structure of complex [SnPh2(L)(DMSO)] (5) shows that the ligand is doubly deprotonated and is coordinated as tridentate ligand.
The six coordination number is completed by two carbon atoms of phenyl groups.
There are two similar monomers 5a (Sn1) and 5b (Sn51) in the asymmetric unit.
The monomers 5a and 5b are linked through intermolecular hydrogen bonds of N–H–O and C–H–S type.
C–H→π, intermolecular interactions, intra- and intermolecular hydrogen bonds stabilize this structure and leads to aggregation and a supramolecular assembly.
The IR and NMR (1H, 13C and 119Sn) spectroscopic data of the complexes are reported.
The in vitro cytotoxic activity has been evaluated against the cells of three human cancer cell lines: MCF-7 (human breast cancer cell line), T-24 (bladder cancer cell line), A-549 (nonsmall cell lung carcinoma) and a mouse L-929 (a fibroblast-like cell line cloned from strain L).
Compounds 1, 3, and 4 were found active against all four cell lines.
Selectivity was observed for complexes 3 and 4 which were found especially active against MCF-7 and T-24 cancer cell lines.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wiecek, Joanna& Kovala-Demertzi, Dimitra& Ciunik, Zbigniew& Zervou, Maria& Demertzis, Mavroudis A.. 2010. Diorganotin Complexes of a Thiosemicarbazone, Synthesis : Properties, X-Ray Crystal Structure, and Antiproliferative Activity of Diorganotin Complexes. Bioinorganic Chemistry and Applications،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-504642
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wiecek, Joanna…[et al.]. Diorganotin Complexes of a Thiosemicarbazone, Synthesis : Properties, X-Ray Crystal Structure, and Antiproliferative Activity of Diorganotin Complexes. Bioinorganic Chemistry and Applications No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-504642
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wiecek, Joanna& Kovala-Demertzi, Dimitra& Ciunik, Zbigniew& Zervou, Maria& Demertzis, Mavroudis A.. Diorganotin Complexes of a Thiosemicarbazone, Synthesis : Properties, X-Ray Crystal Structure, and Antiproliferative Activity of Diorganotin Complexes. Bioinorganic Chemistry and Applications. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-504642
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-504642
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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