Diorganotin Complexes of a Thiosemicarbazone, Synthesis : Properties, X-Ray Crystal Structure, and Antiproliferative Activity of Diorganotin Complexes
Joint Authors
Ciunik, Zbigniew
Zervou, Maria
Demertzis, Mavroudis A.
Kovala-Demertzi, Dimitra
Wiecek, Joanna
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The synthesis and spectral characterization of novel diorganotin complexes with 3-hydroxypyridine-2-carbaldehyde thiosemicarbazone, H2L(1), [SnMe2(L)] (2), [SnBu2(L)] (3), and [SnPh2(L)] (4) are reported.
The single-crystal X-ray structure of complex [SnPh2(L)(DMSO)] (5) shows that the ligand is doubly deprotonated and is coordinated as tridentate ligand.
The six coordination number is completed by two carbon atoms of phenyl groups.
There are two similar monomers 5a (Sn1) and 5b (Sn51) in the asymmetric unit.
The monomers 5a and 5b are linked through intermolecular hydrogen bonds of N–H–O and C–H–S type.
C–H→π, intermolecular interactions, intra- and intermolecular hydrogen bonds stabilize this structure and leads to aggregation and a supramolecular assembly.
The IR and NMR (1H, 13C and 119Sn) spectroscopic data of the complexes are reported.
The in vitro cytotoxic activity has been evaluated against the cells of three human cancer cell lines: MCF-7 (human breast cancer cell line), T-24 (bladder cancer cell line), A-549 (nonsmall cell lung carcinoma) and a mouse L-929 (a fibroblast-like cell line cloned from strain L).
Compounds 1, 3, and 4 were found active against all four cell lines.
Selectivity was observed for complexes 3 and 4 which were found especially active against MCF-7 and T-24 cancer cell lines.
American Psychological Association (APA)
Wiecek, Joanna& Kovala-Demertzi, Dimitra& Ciunik, Zbigniew& Zervou, Maria& Demertzis, Mavroudis A.. 2010. Diorganotin Complexes of a Thiosemicarbazone, Synthesis : Properties, X-Ray Crystal Structure, and Antiproliferative Activity of Diorganotin Complexes. Bioinorganic Chemistry and Applications،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-504642
Modern Language Association (MLA)
Wiecek, Joanna…[et al.]. Diorganotin Complexes of a Thiosemicarbazone, Synthesis : Properties, X-Ray Crystal Structure, and Antiproliferative Activity of Diorganotin Complexes. Bioinorganic Chemistry and Applications No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-504642
American Medical Association (AMA)
Wiecek, Joanna& Kovala-Demertzi, Dimitra& Ciunik, Zbigniew& Zervou, Maria& Demertzis, Mavroudis A.. Diorganotin Complexes of a Thiosemicarbazone, Synthesis : Properties, X-Ray Crystal Structure, and Antiproliferative Activity of Diorganotin Complexes. Bioinorganic Chemistry and Applications. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-504642
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504642