The Domain Landscape of Virus-Host Interactomes

المؤلفون المشاركون

Ping, Jie
Li, Yixue
Zheng, Lu-Lu
Li, Chunyan
Zhou, Yanhong
Hao, Pei

المصدر

BioMed Research International

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-06-04

دولة النشر

مصر

عدد الصفحات

13

التخصصات الرئيسية

الطب البشري

الملخص EN

Viral infections result in millions of deaths in the world today.

A thorough analysis of virus-host interactomes may reveal insights into viral infection and pathogenic strategies.

In this study, we presented a landscape of virus-host interactomes based on protein domain interaction.

Compared to the analysis at protein level, this domain-domain interactome provided a unique abstraction of protein-protein interactome.

Through comparisons among DNA, RNA, and retrotranscribing viruses, we identified a core of human domains, that viruses used to hijack the cellular machinery and evade the immune system, which might be promising antiviral drug targets.

We showed that viruses preferentially interacted with host hub and bottleneck domains, and the degree and betweenness centrality among three categories of viruses are significantly different.

Further analysis at functional level highlighted that different viruses perturbed the host cellular molecular network by common and unique strategies.

Most importantly, we creatively proposed a viral disease network among viral domains, human domains and the corresponding diseases, which uncovered several unknown virus-disease relationships that needed further verification.

Overall, it is expected that the findings will help to deeply understand the viral infection and contribute to the development of antiviral therapy.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Zheng, Lu-Lu& Li, Chunyan& Ping, Jie& Zhou, Yanhong& Li, Yixue& Hao, Pei. 2014. The Domain Landscape of Virus-Host Interactomes. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-504648

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Zheng, Lu-Lu…[et al.]. The Domain Landscape of Virus-Host Interactomes. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-504648

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Zheng, Lu-Lu& Li, Chunyan& Ping, Jie& Zhou, Yanhong& Li, Yixue& Hao, Pei. The Domain Landscape of Virus-Host Interactomes. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-504648

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-504648