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The Domain Landscape of Virus-Host Interactomes
Joint Authors
Ping, Jie
Li, Yixue
Zheng, Lu-Lu
Li, Chunyan
Zhou, Yanhong
Hao, Pei
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-04
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Viral infections result in millions of deaths in the world today.
A thorough analysis of virus-host interactomes may reveal insights into viral infection and pathogenic strategies.
In this study, we presented a landscape of virus-host interactomes based on protein domain interaction.
Compared to the analysis at protein level, this domain-domain interactome provided a unique abstraction of protein-protein interactome.
Through comparisons among DNA, RNA, and retrotranscribing viruses, we identified a core of human domains, that viruses used to hijack the cellular machinery and evade the immune system, which might be promising antiviral drug targets.
We showed that viruses preferentially interacted with host hub and bottleneck domains, and the degree and betweenness centrality among three categories of viruses are significantly different.
Further analysis at functional level highlighted that different viruses perturbed the host cellular molecular network by common and unique strategies.
Most importantly, we creatively proposed a viral disease network among viral domains, human domains and the corresponding diseases, which uncovered several unknown virus-disease relationships that needed further verification.
Overall, it is expected that the findings will help to deeply understand the viral infection and contribute to the development of antiviral therapy.
American Psychological Association (APA)
Zheng, Lu-Lu& Li, Chunyan& Ping, Jie& Zhou, Yanhong& Li, Yixue& Hao, Pei. 2014. The Domain Landscape of Virus-Host Interactomes. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-504648
Modern Language Association (MLA)
Zheng, Lu-Lu…[et al.]. The Domain Landscape of Virus-Host Interactomes. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-504648
American Medical Association (AMA)
Zheng, Lu-Lu& Li, Chunyan& Ping, Jie& Zhou, Yanhong& Li, Yixue& Hao, Pei. The Domain Landscape of Virus-Host Interactomes. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-504648
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504648