Sex Differences in Mechanisms and Outcome of Neonatal Hypoxia-Ischemia in Rodent Models : Implications for Sex-Specific Neuroprotection in Clinical Neonatal Practice
المؤلفون المشاركون
Hill, Courtney A.
Fitch, R. Holly
المصدر
Neurology Research International
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-02-14
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Clinical findings show that male infants with hypoxic-ischemic injury (HI) fare more poorly than matched females on cognitive outcomes.
Rodent models of neonatal hypoxia-ischemia support this difference, with data showing that perinatal brain injury leads to long-term behavioral deficits primarily in male rodents and in female rodents treated with early androgens.
Results support the idea that sex-specific gonadal hormones may modulate developmental response to injury and dovetail with overwhelming evidence of developmental androgen effects on typical brain morphology and behavior.
However, mechanisms underlying sex differences in response to early brain injury may be more complicated.
Specifically, activation of cell death pathways in response to HI may also differ by sex.
In females, the preferential activation of the caspase-dependent apoptotic pathway may actually afford greater protection, potentially due to the actions of X-linked inhibitor of apoptosis (XIAP) within this pathway.
This contrasts the pattern of preferential activation of the caspase-independent pathway in males.
While an integrated model of sex-specific hormonal and genetic modulation of response to early injury remains to be fully elucidated, these findings suggest that infants might benefit from sex-specific neuroprotection following HI injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hill, Courtney A.& Fitch, R. Holly. 2012. Sex Differences in Mechanisms and Outcome of Neonatal Hypoxia-Ischemia in Rodent Models : Implications for Sex-Specific Neuroprotection in Clinical Neonatal Practice. Neurology Research International،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-504678
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hill, Courtney A.& Fitch, R. Holly. Sex Differences in Mechanisms and Outcome of Neonatal Hypoxia-Ischemia in Rodent Models : Implications for Sex-Specific Neuroprotection in Clinical Neonatal Practice. Neurology Research International No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-504678
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hill, Courtney A.& Fitch, R. Holly. Sex Differences in Mechanisms and Outcome of Neonatal Hypoxia-Ischemia in Rodent Models : Implications for Sex-Specific Neuroprotection in Clinical Neonatal Practice. Neurology Research International. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-504678
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-504678
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر