Histone Deacetylase Inhibition and Dietary Short-Chain Fatty Acids

المؤلفون المشاركون

Licciardi, Paul V.
Ververis, Katherine
Karagiannis, Tom C.

المصدر

ISRN Allergy

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-12-26

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الأمراض

الملخص EN

Changes in diet can also have dramatic effects on the composition of gut microbiota.

Commensal bacteria of the gastrointestinal tract are critical regulators of health and disease by protecting against pathogen encounter whilst also maintaining immune tolerance to certain allergens.

Moreover, consumption of fibre and vegetables typical of a non-Western diet generates substantial quantities of short-chain fatty acids (SCFAs) which have potent anti-inflammatory properties.

Dietary interventions such as probiotic supplementation have been investigated for their pleiotropic effects on microbiota composition and immune function.

Probiotics may restore intestinal dysbiosis and improve clinical disease through elevated SCFA levels in the intestine.

Although the precise mechanisms by which such dietary factors mediate these effects, SCFA metabolites such as butyrate also function as histone deacetylase inhibitors (HDACi), that can act on the epigenome through chromatin remodeling changes.

The aim of this review is to provide an overview of HDAC enzymes and to discuss the biological effects of HDACi.

Further, we discuss the important relationship between diet and the balance between health and disease and how novel dietary interventions such as probiotics could be alternative approach for the prevention and/or treatment of chronic inflammatory disease through modulation of the intestinal microbiome.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Licciardi, Paul V.& Ververis, Katherine& Karagiannis, Tom C.. 2011. Histone Deacetylase Inhibition and Dietary Short-Chain Fatty Acids. ISRN Allergy،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-504860

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Licciardi, Paul V.…[et al.]. Histone Deacetylase Inhibition and Dietary Short-Chain Fatty Acids. ISRN Allergy No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-504860

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Licciardi, Paul V.& Ververis, Katherine& Karagiannis, Tom C.. Histone Deacetylase Inhibition and Dietary Short-Chain Fatty Acids. ISRN Allergy. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-504860

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-504860