Brazilian Propolis Suppresses Angiogenesis by Inducing Apoptosis in Tube-Forming Endothelial Cells through Inactivation of Survival Signal ERK12
المؤلفون المشاركون
Eguchi, Ryoji
Fujimori, Yoshihiro
Kumazawa, Shigenori
Nakayama, Tsutomu
Kobayashi, Tomomi
Kunimasa, Kazuhiro
Kaji, Kazuhiko
Ahn, Mok-Ryeon
Nakano, Takashi
Ohta, Toshiro
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-10-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
We recently reported that propolis suppresses tumor-induced angiogenesis through tube formation inhibition and apoptosis induction in endothelial cells.
However, molecular mechanisms underlying such angiogenesis suppression by propolis have not been fully elucidated.
The aim of this study was to investigate the effects of ethanol extract of Brazilian propolis (EEBP) on two major survival signals, extracellular signal-regulated kinase 1/2 (ERK1/2) and Akt, and to elucidate whether changes in these signals were actually involved in antiangiogenic effects of the propolis.
Detection by western blotting revealed that EEBP suppressed phosphorylation of ERK1/2, but not that of Akt.
Pharmacological inhibition by U0126 demonstrated that ERK1/2 inactivation alone was enough to inhibit tube formation and induce apoptosis.
It was also shown that EEBP and U0126 similarly induced activation of caspase-3 and cleavage of poly ADP-ribose polymerase (PARP) and lamin A/C, all of which are molecular markers of apoptosis.
These results indicate that inhibition of survival signal ERK1/2, and subsequent induction of apoptosis, is a critical mechanism of angiogenesis suppression by EEBP.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kunimasa, Kazuhiro& Ahn, Mok-Ryeon& Kobayashi, Tomomi& Eguchi, Ryoji& Kumazawa, Shigenori& Fujimori, Yoshihiro…[et al.]. 2010. Brazilian Propolis Suppresses Angiogenesis by Inducing Apoptosis in Tube-Forming Endothelial Cells through Inactivation of Survival Signal ERK12. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-504941
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kunimasa, Kazuhiro…[et al.]. Brazilian Propolis Suppresses Angiogenesis by Inducing Apoptosis in Tube-Forming Endothelial Cells through Inactivation of Survival Signal ERK12. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-504941
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kunimasa, Kazuhiro& Ahn, Mok-Ryeon& Kobayashi, Tomomi& Eguchi, Ryoji& Kumazawa, Shigenori& Fujimori, Yoshihiro…[et al.]. Brazilian Propolis Suppresses Angiogenesis by Inducing Apoptosis in Tube-Forming Endothelial Cells through Inactivation of Survival Signal ERK12. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-504941
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-504941
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر