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A Mathematical Model of Skeletal Muscle Disease and Immune Response in the mdx Mouse
المؤلفون المشاركون
Evans, Nicholas P.
Laubenbacher, Reinhard
Grange, Robert W.
Jarrah, Abdul Salam
Castiglione, Filippo
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-11
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Duchenne muscular dystrophy (DMD) is a genetic disease that results in the death of affected boys by early adulthood.
The genetic defect responsible for DMD has been known for over 25 years, yet at present there is neither cure nor effective treatment for DMD.
During early disease onset, the mdx mouse has been validated as an animal model for DMD and use of this model has led to valuable but incomplete insights into the disease process.
For example, immune cells are thought to be responsible for a significant portion of muscle cell death in the mdx mouse; however, the role and time course of the immune response in the dystrophic process have not been well described.
In this paper we constructed a simple mathematical model to investigate the role of the immune response in muscle degeneration and subsequent regeneration in the mdx mouse model of Duchenne muscular dystrophy.
Our model suggests that the immune response contributes substantially to the muscle degeneration and regeneration processes.
Furthermore, the analysis of the model predicts that the immune system response oscillates throughout the life of the mice, and the damaged fibers are never completely cleared.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jarrah, Abdul Salam& Castiglione, Filippo& Evans, Nicholas P.& Grange, Robert W.& Laubenbacher, Reinhard. 2014. A Mathematical Model of Skeletal Muscle Disease and Immune Response in the mdx Mouse. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-505049
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jarrah, Abdul Salam…[et al.]. A Mathematical Model of Skeletal Muscle Disease and Immune Response in the mdx Mouse. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-505049
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jarrah, Abdul Salam& Castiglione, Filippo& Evans, Nicholas P.& Grange, Robert W.& Laubenbacher, Reinhard. A Mathematical Model of Skeletal Muscle Disease and Immune Response in the mdx Mouse. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-505049
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-505049
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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