A Mathematical Model of Skeletal Muscle Disease and Immune Response in the mdx Mouse
Joint Authors
Evans, Nicholas P.
Laubenbacher, Reinhard
Grange, Robert W.
Jarrah, Abdul Salam
Castiglione, Filippo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Duchenne muscular dystrophy (DMD) is a genetic disease that results in the death of affected boys by early adulthood.
The genetic defect responsible for DMD has been known for over 25 years, yet at present there is neither cure nor effective treatment for DMD.
During early disease onset, the mdx mouse has been validated as an animal model for DMD and use of this model has led to valuable but incomplete insights into the disease process.
For example, immune cells are thought to be responsible for a significant portion of muscle cell death in the mdx mouse; however, the role and time course of the immune response in the dystrophic process have not been well described.
In this paper we constructed a simple mathematical model to investigate the role of the immune response in muscle degeneration and subsequent regeneration in the mdx mouse model of Duchenne muscular dystrophy.
Our model suggests that the immune response contributes substantially to the muscle degeneration and regeneration processes.
Furthermore, the analysis of the model predicts that the immune system response oscillates throughout the life of the mice, and the damaged fibers are never completely cleared.
American Psychological Association (APA)
Jarrah, Abdul Salam& Castiglione, Filippo& Evans, Nicholas P.& Grange, Robert W.& Laubenbacher, Reinhard. 2014. A Mathematical Model of Skeletal Muscle Disease and Immune Response in the mdx Mouse. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-505049
Modern Language Association (MLA)
Jarrah, Abdul Salam…[et al.]. A Mathematical Model of Skeletal Muscle Disease and Immune Response in the mdx Mouse. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-505049
American Medical Association (AMA)
Jarrah, Abdul Salam& Castiglione, Filippo& Evans, Nicholas P.& Grange, Robert W.& Laubenbacher, Reinhard. A Mathematical Model of Skeletal Muscle Disease and Immune Response in the mdx Mouse. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-505049
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505049